This mechanistic study's aim is to assess the DNA damage repair capabilities of afamelanotide in healthy volunteers with skin type I-III following exposure to ultraviolet radiation (UVR)-induced DNA damage.

Inclusion Criteria:

• Healthy male or female volunteers (aged 18-45) with Fitzpatrick skin types I, II or III.
• Written informed consent obtained from volunteers prior to study-start.

Exclusion Criteria:

• Female who is pregnant or lactating.
• Females of child-bearing potential not using adequate contraceptive measures or a lifestyle excluding pregnancy.
• Sexually active man with a partner of child-bearing potential who is not using adequate contraceptive measures.
• Any significant illness during the four weeks before the study screening period.
• Taking known photosensitisers.