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| Name | Class |
|---|---|
| Western Health, Australia | OTHER_GOV |
| Northern Hospital, Australia | OTHER |
| Menzies Institute for Medical Research | OTHER |
| Peter MacCallum Cancer Centre, Australia |
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REDEEM-CAD is a prospective multi-centre study of CAD risk evaluation and management in cancer survivors 40-70 years with chemotherapy or radiotherapy >5 years ago.
REDEEM-CAD is a prospective multi-centre study in which a process of evaluating the risk of coronary artery disease is studied in cancer survivors 40-70 years with chemotherapy or radiotherapy >5 years ago. The efficacy of this CAD risk evaluation will be compared with the broad community in two existing studies - CAUGHT-CAD and EDCAD. This unique Screening/Management Plan (SMP) has 2 components; 1) A novel clinical and imaging-based screening algorithm to select those most likely to develop coronary artery disease, 2) A clinical review to ensure optimal risk factor control and cardio protection.
Follow-up of treated patients will continue for an average of 36 months, with clinic reviews at 12, 24 and 36 months. The results will define the prevalence of subclinical coronary artery disease, and the feasibility and the efficacy of the SMP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Survivor Screening/Management Plan | In cancer survivors;
|
| |
| Non-cancer Screening/Management Plan | In matched non-cancer patients (from EDCAD trial);
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronary CT | Diagnostic Test | Screening/Management Plan |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of evaluated patients who should undergo CAD prevention | High clinical risk, or intermediate risk with CAC score >0 | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion with critical CAD | Coronary stenosis >70% by CT coronary angiogram | 3 years |
| Proportion at intermediate clinical risk | Intermediate clinical risk (0.8-2.0% annualized risk by Pooled Cohort Equation) |
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Inclusion Criteria:
A history of cancer >5 y ago associated with potential cardiotoxicity from chemotherapy and/or radiotherapy (chiefly survivors of breast cancer, Hodgkin's lymphoma and prostate cancer).
Exclusion Criteria:
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Cancer survivors 40-70 years with chemotherapy or radiotherapy >5 years ago
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tom Marwick, MBBS,PhD,MPH | Contact | +61 3 8532 1550 | tom.marwick@baker.edu.au | |
| Lisa Riddell | Contact | +61 3 8532 1550 | lisa.riddell@baker.edu.au |
| Name | Affiliation | Role |
|---|---|---|
| Tom Marwick, MBBS,PhD,MPH | Baker Heart and Diabetes Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tom Marwick | Recruiting | Hobart | Tasmania | 7000 | Australia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39905553 | Derived | Soh CH, Smith J, Shrestha S, Nolan M, Wong J, Nerlekar N, Marwick TH. Screening for coronary artery disease among cancer survivors: rationale and design of the REDEEM-CAD study. Cardiooncology. 2025 Feb 4;11(1):10. doi: 10.1186/s40959-025-00308-7. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| OTHER |
| The Alfred | OTHER |
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Coronary CT scans
| 3 years |
| Statin responsiveness | Change in plaque volume | 3 year follow-up |
| Baker Heart and Diabetes Institute | Recruiting | Melbourne | Victoria | 3004 | Australia |
|
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |