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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-01788 | Other Grant/Funding Number | FoUI-960460 |
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| Name | Class |
|---|---|
| Swedish Council for Working Life and Social Research | OTHER |
| Center for Innovative Medicine | UNKNOWN |
| Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse | UNKNOWN |
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This study aims to examine 1) if multicomponent exercise interventions (including both mobility and strengthening exercises) have effects on physical function compared to usual care in older adults, and 2) if a comprehensive multicomponent exercise program is more effective than a simple multicomponent exercise program including only walking and rising from a chair.
This is a three-armed randomized controlled trial, with two intervention groups (comprehensive and simple exercise program) and a control group receiving usual care. Participants aged ≥75 years will be included consecutively from geriatric medical wards of hospitals in Stockholm, Sweden. Assessments will be conducted at hospital admission, discharge and three months thereafter concerning physical function (primary outcome), activities of daily living, health-related quality of life, sarcopenia, and falls. Number of re-admissions and mortality will be registered up to 1 year after discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention 1 (simple exercise program) | Experimental | The intervention will include up to four sessions per day. It consists of sit-to stand exercises and walking along the corridor of the ward (for those who can walk). |
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| Intervention 2 (comprehensive exercise program) | Experimental | This intervention consists of two daily sessions (morning and afternoon). The morning session includes individualized supervised progressive resistance, balance, and walking training exercises, tailored to each participant's capacity. The resistance training includes using weight cuffs, involving mainly lower-extremity muscles. Balance and gait exercises includes different exercises such as line walking, stepping practice, and walking with small obstacles. The evening session consists of functional exercises using light loads, such as knee extension and flexion, hand training with a ball, and daily walking exercises (for those who can walk). |
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| Control group | No Intervention | The control group will receive usual care, which may include physical rehabilitation when needed. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intervention 1 (simple exercise program) | Other | Up to four sessions per day (total duration 20-30 minutes/day). Performed at the hospital on all weekdays from baseline until hospital discharge (around 1 week). At discharge, the participants will be encouraged to continue with the exercise program at home. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical function | Short Physical Performance Battery (Possible score: 0-12), a higher score represents a better physical function) | Change from baseline (hospital admission) to completion of the hospital-based exercises (at discharge around 1 week after baseline) |
| Physical function | Short Physical Performance Battery (Possible score: 0-12), a higher score represents a better physical function) | Change from baseline (hospital admission) to 3 months after discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Activities of daily living | Barthel Index (Possible score: 0-100, a higher score represents a better functional ability) | Change from baseline (hospital admission) to completion of the hospital-based exercises (at discharge around 1 week after baseline) |
| Activities of daily living |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anna-Karin Welmer, PhD | Contact | +46852488804 | anna-karin.welmer@ki.se |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Anna-Karin Welmer | Recruiting | Huddinge | 141 83 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38905174 | Derived | Sandberg L, Bostrom AM, Hagstromer M, Lindgren C, Kivipelto M, Sandlund C, Welmer AK. Feasibility of the "Preventing functional decline in acutely hospitalized older patients (PREV_FUNC)" study-A three-armed randomized controlled pilot trial. PLoS One. 2024 Jun 21;19(6):e0304570. doi: 10.1371/journal.pone.0304570. eCollection 2024. | |
| 37607787 |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| Intervention 2 (comprehensive exercise program) | Other | Two daily sessions (morning and afternoon) of 20 minutes' duration each. Performed at the hospital on all weekdays from baseline until hospital discharge (around 1 week). |
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Barthel Index (Possible score: 0-100, a higher score represents a better functional ability) |
| Change from baseline (hospital admission) to 3 months after discharge |
| Health related quality of life | EuroQol-5 Dimension | Change from baseline (hospital admission) to completion of the hospital-based exercises (at discharge around 1 week after baseline) |
| Health related quality of life | EuroQol-5 Dimension | Change from baseline (hospital admission) to 3 months after discharge |
| Sarcopenia | Defined by grip strength and calf- and arm circumferences according to the European Working Group's revised criteria on Sarcopenia in Older People | Change from baseline (hospital admission) to completion of the hospital-based exercises (at discharge around 1 week after baseline) |
| Sarcopenia | Defined by grip strength and calf- and arm circumferences according to the European Working Group's revised criteria on Sarcopenia in Older People | Change from baseline (hospital admission) to 3 months after discharge |
| Number of falls | According to the logbooks at the hospital | Change from baseline (hospital admission) to completion of the hospital-based exercises (at discharge around 1 week after baseline) |
| Number of falls | According to self-report | From hospital discharge to 3 months after discharge |
| Mortality data | Data on vital status will be collected using administrative data | Up to 1 year after hospital discharge |
| Number of readmissions | Data on readmissions will be collected using administrative data | Up to 1 year after hospital discharge |
| Welmer AK, Sandberg L, Sandlund C, Bjorck C, Hagstromer M, Hamilton J, Helgstrand G, Lindgren C, Nordstrand L, Sandstedt P, Kivipelto M, Bostrom AM. Study protocol for the 'preventing functional decline in acutely hospitalised older patients (PREV_FUNC)' study: effects of two multicomponent exercise programmes on physical function - a three-armed randomised controlled trial. BMJ Open. 2023 Aug 22;13(8):e070885. doi: 10.1136/bmjopen-2022-070885. |