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| Name | Class |
|---|---|
| Regional Dermatology Training Centre (RDTC), Moshi, Tanzania | UNKNOWN |
| University Hospital Joseph Raseta Befelatanana in Antananarivo, Madagascar | UNKNOWN |
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Many people are affected by atopic dermatitis (AD) worldwide. However, clinical studies on AD in Sub-Saharan Africa are rare and there is a lack of knowledge about possible differences in pathogenesis between European and African AD.
This study will collect clinical and laboratory data with the aim to compare clinical characteristics and immune responses in AD patients in Sub-Saharan Africa and Central Europe. Furthermore, relevant allergens as well as the nasal, skin and gut micro- and mycobiome will be investigated.
Objectives of the project: Compare the following aspects in patients suffering from atopic dermatitis (AD) and healthy control (HC) participants in Central Europe (CE) vs. Sub-Saharan Africa (SsA):
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atopic Dermatitis (Europe) |
| ||
| Healthy Controls (Europe) |
| ||
| Atopic Dermatitis (Tanzania) |
| ||
| Healthy Controls (Tanzania) |
| ||
| Atopic Dermatitis (Madagascar) |
| ||
| Healthy Controls (Madagascar) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observation | Other | Questionnaires, Clinical Scores, Biomaterial Sampling |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total and specific IgE and IgG levels | Will be put into clinical context with a questionnaire about food intake and allergic symptoms | Day 0 |
| Questionnaire about food intake | Information about how often the participants are consuming certain foods | Day 0 |
| Questionnaire about the presence of allergic symptoms | Information about symptoms upon allergen exposure | Day 0 |
| Description of clinical appearance of AD on black vs. white skin | Appearance, severity and distribution of the skin lesions | Day 0 |
| Stigmata of atopic constitution | The presence of atopic stigmata will be clinically assessed by study doctors by using a structured form | Day 0 |
| Skin microbiome (microbial colonization of the skin) |
| Day 0 |
| Change of the skin microbiome components over time |
| Day 0 and day 28 |
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Inclusion Criteria:
AD patients:
HC participants:
Exclusion Criteria:
Known or suspected systemic immunosuppression because of disease
Systemic immunomodulatory/-suppressive treatment
Clinical signs of active bacterial, fungal or viral infection
Systemic antibiotic, antimycotic or antiviral treatment 4 weeks prior to start
Phototherapy 4 weeks prior to start
Active neoplasia
Undergoing surgery in the last 2 months
Infarction (e.g. stroke), embolism, or thrombosis in the last 2 months
Inability to follow the study procedures e.g. due to language problems, dementia etc. of the participant
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Patients with active atopic dermatitis and healthy control participants
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| Name | Affiliation | Role |
|---|---|---|
| Marie-Charlotte Brüggen, Prof. | University of Zurich | Principal Investigator |
| Daudi Mavura, Prof. | RDTC Moshi | Principal Investigator |
| John Masenga, Prof. | RDTC Moshi | Principal Investigator |
| Fandresena Sendrasoa, Dr. | University Hospital Joseph Raseta Befelatanana | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Joseph Raseta Befelatanana | Antananarivo | Madagascar | ||||
| University Hospital Zurich |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36468335 | Derived | Fehr D, Lang C, Masenga J, Mavura D, Schmid-Grendelmeier P, Bruggen MC. Atopic dermatitis: The importance of future research in Africa. Allergy. 2023 Jan;78(1):327-328. doi: 10.1111/all.15422. Epub 2022 Dec 5. No abstract available. |
| Label | URL |
|---|---|
| Flyer (University Hospital Zurich) | View source |
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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| Nasal microbiome (microbial colonization of the nasal vestibule) |
| Day 0 |
| Gut microbiome (microbial colonization of the gut) | Analysis by isolation and sequencing of the microbial DNA | Day 0 |
| Cutaneous immune response |
| Day 0 |
| Systemic immune response | Olink multiplex proteomics analyses and characterization of PBMCs will be performed | Day 0 |
| Change of molecular and cellular mediators of the systemic immune response over time | Olink multiplex proteomics analyses and characterization of PBMCs will be performed | Day 0 and day 28 |
| Barrier dysfunction of the skin (Imaging Mass Cytometry) | Skin biopsies are optional and will be taken from lesional and non-lesional skin | Day 0 |
| Barrier dysfunction of the skin (Spatial gene expression analysis) | Skin biopsies are optional and will be taken from lesional and non-lesional skin | Day 0 |
| Family history of atopic diseases | - Assessment of whether parents, siblings or other family members suffer from atopic diseases | Day 0 |
| Questionnaire about current treatments | Participants will be asked about their intake of medication and their use of topical treatments | Day 0 |
| Life Quality measured by Dermatology Life Quality Index (DLQI) |
| Day 0 |
| Zurich |
| Switzerland |
| Regional Dermatology Training Centre (RDTC) | Moshi | Tanzania |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |