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Studies have demonstrated that the rate of change in stroke volume variation (SVV) can be used to determine the volume of body fluids during major abdominal surgery. Anaesthesiologists can use SVV as a guide for the appropriate administration of intraoperative fluids to improve postoperative prognoses. Liver surgery is a major abdominal operation, and the amount of blood lost is typically higher than that during other general abdominal surgeries. Blood loss is positively correlated with the intraoperative fluid infusion volume, and greater blood loss is associated with more postoperative complications. Additionally, comorbid liver disease or cirrhosis can increase the complexity of liver tumour resection, causing difficulty in assessing intravascular volume and determining the appropriate intraoperative infusion volume.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the low-SVV group | Active Comparator | the value of stroke volume variation will be less than or equal to 10 this group |
|
| the high-SVV group | Active Comparator | the value of stroke volume variation will be higher than 10 this group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SVV-guided fluid management | Procedure | fluid will be guided by value of stroke volume variation |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of postoperative complications in the two groups. | calculate the incidence of postoperative complication within 30 days | From day 1 to day 30 after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| The differences of perioperative ALT | Calculate the difference of the perioperative physiological variables | Examination report on the 1st postoperative day. |
| The differences of perioperative eGFR |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yuan-Yi Chia, Director | Kaohsiung Veterans General Hospital. | Principal Investigator |
| Kai-Wei Hsieh, physician | Kaohsiung Veterans General Hospital. | Study Director |
| We-Yu Chen, physician | Kaohsiung Veterans General Hospital. | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Veterans General Hospital | Kaohsiung City | 81362 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11473870 | Background | Lang K, Boldt J, Suttner S, Haisch G. Colloids versus crystalloids and tissue oxygen tension in patients undergoing major abdominal surgery. Anesth Analg. 2001 Aug;93(2):405-9 , 3rd contents page. doi: 10.1097/00000539-200108000-00034. |
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This trial had a randomised study design with simple randomisation and a fixed allocation ratio (1:1 to the low-SVV group or high-SVV group). The patients were blinded to the randomisation and allocation.
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Calculate the difference of the perioperative physiological variables
| Examination report on the 1st postoperative day. |
| The differences of perioperative creatinine | Calculate the difference of the perioperative physiological variables | Examination report on the 1st postoperative day. |
| The differences of perioperative T.bil | Calculate the difference of the perioperative physiological variables | Examination report on the 1st postoperative day. |
| The differences of perioperative Hb | Calculate the difference of the perioperative physiological variables | Examination report on the 1st postoperative day. |
| The differences of perioperative arterial lactate | Calculate the difference of the perioperative physiological variables | Examination report on the 1st postoperative day. |
| The differences of perioperative albumin | Calculate the difference of the perioperative physiological variables | Examination report on the 1st postoperative day. |
| The pain scale | Assessment of postoperative pain scale | up to three days postoperatively |
| Background |
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