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The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diagnostic (DSC MRI) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) | Diagnostic Test | A dye, known as a contrast agent, will be injected through a needle that is inserted into a vein in the arm or hand. Subsequent magnetic resonance imaging will follow. |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of perfusion parameter: cerebral blood volume (CBV) | Measurements of cerebral blood volume (CBV) will be calculated. | Baseline to end of study (up to 2 years) |
| Measurement of perfusion parameter: vessel size index (VSI) | Measurements of vessel size index (VSI) will be calculated. | Baseline to end of study (up to 2 years) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Angelica Manalac | Contact | 4166035800 | 3193 | dual.perfusion@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Paula Alcaide-Leon, MD | University Health Network, Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Health Network | Recruiting | Toronto | Ontario | M5G 2C4 | Canada |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D000098642 | Perfusion Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D003933 | Diagnosis |