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Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Electrical Stimulation group | Experimental | Epidural Electrical Stimulation of the Cervical Spinal Cord |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| epidural electrical stimulation | Device | Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in respiratory frequency | Increase or decrease in respiratory frequency of 20% during or after stimulation | During intraoperative surgery during stimulation and within 2 minutes after stimulation |
| Change in respiratory tidal volume | Increase or decrease in respiratory tidal volume of 20% during or after stimulation | During intraoperative surgery during stimulation and within 2 minutes after stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Change in heart rate | Increase or decrease in heart rate of 20% during or after stimulation | During intraoperative surgery during stimulation and within 2 minutes after stimulation |
| Change in blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Daniel Lu, MD | Contact | 310/825/4321 | dclu@mednet.ucla.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, Los Angeles | Recruiting | Los Angeles | California | 90095 | United States |
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| ID | Term |
|---|---|
| D007405 | Intervertebral Disc Displacement |
| D055009 | Spondylosis |
| ID | Term |
|---|---|
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D006547 | Hernia |
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Increase or decrease in blood pressure of 20% during or after stimulation
| During intraoperative surgery during stimulation and within 2 minutes after stimulation |
| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |