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Perioperative respiratory adverse events are common in children. We aimed to evaluate the effect of sugammadex on the incidence of perioperative respiratory adverse events in pediatric patients receiving tonsillectomy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sugammadex as reversal agent | Experimental |
| |
| Neostigmine as reversal agent | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sugammadex injection | Drug | sugammadex as reversal agent |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Perioperative respiratory adverse events | the incidence of overall perioperative respiratory adverse events; oxygen desaturation < 95%, airway obstruction, laryngospasm, bronchospasm, severe coughing, or postoperative stridor | from induction of anesthesia to end of operation, about 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| bradycardia | administration of IV atropine, glycopyrrolate, epinephrine, ephedrine | from induction of anesthesia to end of operation, about 3 hours |
| Cardiac arrest | documented chest compressions/defibrillation/cardioversion |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul national university hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D000077122 | Sugammadex |
| D009388 | Neostigmine |
| ID | Term |
|---|---|
| D047408 | gamma-Cyclodextrins |
| D003505 | Cyclodextrins |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
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| Neostigmine |
| Drug |
neostigmine as a reversal agent |
|
| from induction of anesthesia to end of operation, about 3 hours |
| Anaphylaxis | administration of epinephrine, methylprednisolone, diphenhydramine, documented diagnosis of anaphylactic/ anaphylatoid reaction | from induction of anesthesia to end of operation, about 3 hours |
| Allergic reaction | redness, urticaria, wheeze | from induction of anesthesia to end of operation, about 3 hours |
| Bronchospasm | administration of albuterol, epinephrine | from induction of anesthesia to end of operation, about 3 hours |
| Nausea and vomiting | from induction of anesthesia to end of operation, about 3 hours |
| D003912 |
| Dextrins |
| D013213 | Starch |
| D005936 | Glucans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D050338 | Phenylammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009861 | Onium Compounds |