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| Name | Class |
|---|---|
| University of Bialystok | OTHER_GOV |
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The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging
In this study, it is planned to find twenty volunteers for each of the neuropathies and twenty healthy volunteers. Each volunteer will undergo clinical tests such as visual acuity, color vision, intraocular pressure measurement, assessment of the anterior chamber and fundus using a slit lamp and Volk lens, macular optical coherence tomography examination and examination of the optic nerve disc (OCT), neurological field vision and visual evoked potential (VEP) testing. Each of the volunteers will undergo magnetic resonance imaging. During active scanning, patients will be asked for not blinking or moving their heads by staring at the red dot on the outside of the camera reflected in the coil mirror. The obtained diffusion tensor data will be used for further analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Various types of optic neuropathies | Experimental | Patients with various types of optic neuropathy. |
|
| Healthy volunteers | Other | Healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuroimaging | Device | Magnetic resonance diffusion tensor imaging of the brain |
|
| Measure | Description | Time Frame |
|---|---|---|
| sigma parameter | sigma parameter in our algorithm provides a quantitative measure of nerve atrophy | one month |
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Inclusion Criteria:
Optic neuropathy.
Exclusion Criteria:
common contraindications to MRI (presence of pacemaker, non-MRI-safety or claustrophobia)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lisowski | Recruiting | Wasilków | 16010 | Poland |
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Two groups: volunteers with neuropathies and healthy volunteers
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| VEP - visual evoked potential | Diagnostic Test | Electrophysiology of the visual pathway. |
|
| Ophthalmology examination. | Diagnostic Test | Full ophthalmological examination (visual acuity, color vision, measurement of intraocular pressure, evaluation of the anterior chamber and the fundus of the eye using a slit lamp and the Volk lens, optical coherence tomography examination of the macula and optic nerve disc (OCT), neurological field vision) |
|
| ID | Term |
|---|---|
| D018917 | Optic Neuropathy, Ischemic |
| D009902 | Optic Neuritis |
| D020221 | Optic Nerve Injuries |
| D000081028 | Toxic Optic Neuropathy |
| D009901 | Optic Nerve Diseases |
| ID | Term |
|---|---|
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020209 | Cranial Nerve Injuries |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D064420 | Drug-Related Side Effects and Adverse Reactions |
| D064419 | Chemically-Induced Disorders |
| D011832 | Radiation Injuries |
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| ID | Term |
|---|---|
| D059906 | Neuroimaging |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |
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