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Ruptured endometrioma cases were compared with unruptured endometrioma cases.
This study aims to compare the findings in patients who had surgery for ruptured endometrioma with the patients who had an unruptured endometrioma.
This study was conducted at Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic and all patients who were operated for endometrioma and had a histopathology report confirming the presence of endometrioma between January 2014 and December 2020 were included.
In this study, demographic characteristics, intraoperative findings, laboratory values and follow-up recommendations of two groups compared. The patients' age, presence of sexual activity and/or infertility, gravidity, parity, abortion, history of ectopic pregnancy, accompanying systemic disease, previous operations, drug use, and symptoms were recorded. Preoperative and postoperative complete blood count, Cancer antigen 125 (CA 125), Cancer antigen 19-9 (CA19-9), Cancer antigen 15-3 (CA 15-3), Carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), anti mullerian hormone (AMH), fibrinogen, C-reactive protein (CRP) values of the patients were obtained. Patient files, operation notes and laboratory values of the electronic recording system database and the two groups were compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Operated Non-Ruptured Endometrioma Group | It consists of patients who were found to have endometrioma in their clinical follow-ups and decided to operate as a result of the evaluations. The patients were operated under elective conditions. |
| |
| Operated Ruptured Endometrioma Group | Rupture of endometrioma, which is a rare gynecological emergency. This group consists of endometrioma patients requiring urgent/subacute operation such as acute abdominal pain, hemodynamic instability, intra-abdominal bleeding. The patients were operated after completing the necessary preparations |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopy/Laparotomy | Procedure | All patients included in the study were operated patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pre-interventional Comparison of inflammatory parameters | Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), Monocyte/Lymphocyte ratio (MLR) were compared between two groups in the preoperative period | Blood samples were taken from the patients before the surgery |
| Comparison of inflammatory parameters after surgery | Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), Monocyte/Lymphocyte ratio (MLR) were compared between two groups in the postoperative period | Blood samples were taken from the patients in the first postoperative day. |
| Pre-interventional Comparison of tumor markers | Cancer antigens; CA125, CA19-9 and CA 15-3 were compared between two groups in the preoperative period | Blood samples were taken from the patients before the surgery |
| Comparison of tumor markers after surgery | Cancer antigens; CA125, CA19-9 and CA 15-3 were compared between two groups in the postoperative period | Blood samples were taken from the patients after the surgery up to 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Sexual activity | The existence of sexual activity in each study group was questioned. | Before surgery |
| Infertility | The existence of infertility in each study group was questioned. |
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Inclusion Criteria:
Exclusion Criteria:
The research was conducted on female patients.
Patients who were operated on in Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic, whose histopathological diagnosis was confirmed as endometrioma. All patients were women of reproductive age with a pelvic mass.
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| Name | Affiliation | Role |
|---|---|---|
| Berna Dilbaz, Prof. | Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic's Chief | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic | Ankara | Keçiören | 06050 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26403090 | Background | Dai X, Jin C, Hu Y, Zhang Q, Yan X, Zhu F, Lin F. High CA-125 and CA19-9 levels in spontaneous ruptured ovarian endometriomas. Clin Chim Acta. 2015 Oct 23;450:362-5. doi: 10.1016/j.cca.2015.09.019. Epub 2015 Sep 25. | |
| 22030044 | Background | Huang YH, Liou JD, Hsieh CL, Shiau CS, Lo LM, Chang MY. Long-term follow-up of patients surgically treated for ruptured ovarian endometriotic cysts. Taiwan J Obstet Gynecol. 2011 Sep;50(3):306-11. doi: 10.1016/j.tjog.2010.05.002. |
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| D012421 | Rupture |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D010535 | Laparoscopy |
| D007813 | Laparotomy |
| ID | Term |
|---|---|
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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all patients who were operated for endometrioma and had a histopathology report confirming the presence of endometrioma Surgical materials were biospecimens, which had a histopathology report confirming the presence of endometrioma
| Before surgery |
| 26166344 | Result | Tanaka K, Kobayashi Y, Dozono K, Shibuya H, Nishigaya Y, Momomura M, Matsumoto H, Iwashita M. Elevation of plasma D-dimer levels associated with rupture of ovarian endometriotic cysts. Taiwan J Obstet Gynecol. 2015 Jun;54(3):294-6. doi: 10.1016/j.tjog.2014.09.010. |
| D000091662 | Genital Diseases |
| D014947 | Wounds and Injuries |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |