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| Name | Class |
|---|---|
| University of Edinburgh | OTHER |
| Universidad de Granada | OTHER |
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Hospital acquired thrombosis describes blood clots that form in the legs and lungs after someone is treated in hospital. Clots in the leg can cause swelling, pain and other problems. If a clot in the leg travels to the lungs, it may be life threatening. Having surgery increases the risk of developing blood clots.
People having short-stay surgery (who either go home the same day or who stay overnight but go home shortly afterwards) are at a much lower risk of developing a blood clot than those who stay in hospital for longer. These low-risk people are often given elastic stockings (which squeeze the leg muscles) to reduce the chance of a blood clot.
The risks of wearing the stockings are low but they can be uncomfortable. In the UK, there are over a million short stay surgeries performed each year and most of these people are given elastic stockings to wear. Stockings cost the NHS a lot of money and it remains unknown if they work.
This study will investigate if it is worthwhile to continue using elastic stockings in people having surgery where the risk of developing blood clots is low. Adults (over 18-years) who are at low risk of developing blood clots (assessed using a nationally recognised tool) will be included.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control - No graduated compression stockings | No Intervention | In those centres randomised to the control arm, participants will not receive Graduated Compression Stockings (GCS). | |
| Intervention - The provision of graduated compression stockings | Experimental | Centres randomised to the intervention arm, which is the current standard of care, will consist of participants receiving Graduated Compression Stockings (GCS). Clinical staff (e.g. theatre support workers) will issue stockings to all patients who are scheduled to undergo short-stay surgery. Participants will be instructed to wear their stockings just before undergoing the surgical procedure and to remove the stockings as soon as they are ambulant (i.e. after the procedure). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Graduated Compression Stockings - Thromboembolic deterrent stockings | Other | Centres randomised to the intervention arm will consist of participants receiving GCS. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The rate of symptomatic VTE within 90 days | The rate of symptomatic VTE for surgical patients undergoing short-stay procedures assessed as being at low-risk of VTE | 90-days |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | 90-days | |
| Quality of Life | Quality of Life assessed using the EQ-5D | 7 and 90-days |
| Adverse events related to GCS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sarah Whittley | Contact | 0203 311 7371 | s.whittley@imperial.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Alun Davies | Imperial College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barnsley Hospital NHS Foundation Trust | Recruiting | Barnsley | United Kingdom | |||
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Adverse events related to GCS for those in the intervention arm only |
| 7-days |
| Health Economic Outcome | Incremental Cost-Effectiveness Ratio (ICER) | 2 years |
| Frimley Health NHS Foundation Trust |
| Recruiting |
| Camberley |
| United Kingdom |
| Queen Victoria Hospital NHS Foundation Trust | Recruiting | East Grinstead | United Kingdom |
| Imperial College Hospital NHS Foundation Trust | Recruiting | London | United Kingdom |
| South Tees Hospitals NHS Foundation Trust | Recruiting | Middlesbrough | United Kingdom |
| The Newcastle upon Tyne Hospitals NHS Foundation Trust | Recruiting | Newcastle upon Tyne | United Kingdom |
| Sherwood Forest Hospital NHS Foundation Trust | Recruiting | Nottingham | United Kingdom |
| North Tees and Hartlepool NHS Foundation Trust | Recruiting | Stockton-on-Tees | United Kingdom |
| Somerset NHS Foundation Trust | Recruiting | Taunton | United Kingdom |
| ID | Term |
|---|---|
| D054556 | Venous Thromboembolism |
| D020246 | Venous Thrombosis |
| D011655 | Pulmonary Embolism |
| ID | Term |
|---|---|
| D013923 | Thromboembolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013927 | Thrombosis |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D004617 | Embolism |
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