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| Name | Class |
|---|---|
| University of Michigan | OTHER |
| University of Pennsylvania | OTHER |
| Stanford University | OTHER |
| Patient-Centered Outcomes Research Institute |
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To evaluate the feasibility of a pragmatic, large scale, comparative effectiveness, randomized evaluation of patient experience of intravenous propofol versus inhaled volatile anesthesia.
Two-center single-blinded randomized feasibility study, with randomization 1:1 to either propofol TIVA or inhaled volatile general anesthesia for patients who are receiving elective non-cardiac surgery. Patients will be stratified by clinical site with 150 participants per site.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol total intravenous anesthesia (TIVA) | Active Comparator | No administration of inhaled agent. |
|
| Inhaled volatile general anesthesia | Active Comparator | Must administer inhaled agent. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anesthetic technique Propofol TIVA | Other | Propofol TIVA no inhaled agent |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion participating | Proportion of patients who are approached to participate by the study team and who consent to participate in the study. | 8 months |
| Proportion receiving TIVA | Proportion of patients in the propofol TIVA group who receive per protocol treatment (i.e. they receive no inhaled agents as part of their anesthetic). | 8 months |
| Proportion receiving inhaled anesthesia | Proportion of patients in the inhaled volatile group who receive per protocol treatment (i.e. they do receive inhaled agents as part of their anesthetic). | 8 months |
| Measure | Description | Time Frame |
|---|---|---|
| Completeness of data collection | Completeness of data collection (defined as the percentage of instruments or data fields completed with at least 90% of expected forms or relevant fields completed at each time point and with each instrument) | 11 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sachin Kheterpal, MD | University of Michigan | Principal Investigator |
| Michael S Avidan, MBBcH | Washington Univeristy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94305 | United States | ||
| University of Michigan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41950401 | Derived | Janda AM, Tellor Pennington BR, Colquhoun DA, Kumar SS, Neuman MD, Politi MC, Spino C, Kidwell KM, Swisher L, Bollini M, Vaughn MT, Cloyd C, Pescatore NA, Thelen-Perry S, Gregory SH, du Toit L, Henrichs B, Torres B, Avidan MS, Kheterpal S; THRIVE research group. Feasibility Pilot Trial for the Trajectories of Recovery after Intravenous Propofol versus Inhaled Volatile Anesthesia (THRIVE) Pragmatic Randomized Clinical Trial. Anesthesiology. 2026 Jul 1;145(1):59-71. doi: 10.1097/ALN.0000000000006089. Epub 2026 Apr 8. | |
| 37068889 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 16, 2024 | |
| Reset | Sep 13, 2024 | |
| Release | Dec 31, 2025 |
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| OTHER |
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| Anesthetic technique inhaled agent | Other | must administer inhaled agent. |
|
|
| Ann Arbor |
| Michigan |
| 48109 |
| United States |
| Washington University School of Medicine | St Louis | Missouri | 63110 | United States |
| Hosptial of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States |
| Derived |
| Tellor Pennington BR, Colquhoun DA, Neuman MD, Politi MC, Janda AM, Spino C, Thelen-Perry S, Wu Z, Kumar SS, Gregory SH, Avidan MS, Kheterpal S; THRIVE research group. Feasibility pilot trial for the Trajectories of Recovery after Intravenous propofol versus inhaled VolatilE anesthesia (THRIVE) pragmatic randomised controlled trial. BMJ Open. 2023 Apr 17;13(4):e070096. doi: 10.1136/bmjopen-2022-070096. |
| Reset | Jan 20, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 16, 2024 | Sep 13, 2024 | |||
| Dec 31, 2025 | Jan 20, 2026 |
| ID | Term |
|---|---|
| D058926 | Intraoperative Awareness |
| D000071257 | Emergence Delirium |
| D010149 | Pain, Postoperative |
| D020250 | Postoperative Nausea and Vomiting |
| D003863 | Depression |
| D020178 | Sleep Disorders, Circadian Rhythm |
| ID | Term |
|---|---|
| D007431 | Intraoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D011183 | Postoperative Complications |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D010146 | Pain |
| D009325 | Nausea |
| D012817 | Signs and Symptoms, Digestive |
| D014839 | Vomiting |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D021081 | Chronobiology Disorders |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009784 | Occupational Diseases |
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