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A case-control study to assess the association between the risk of diabetic retinopathy in Egyptians and genetic polymorphism of both EPO and SLMAP genes.
Traditional environmental risk factors, such as glycemic control and duration of diabetes, failed to fully explain why some individuals remain protected while others progress to severe diabetic retinopathy.
Several studies suggest variations in diabetic retinopathy prevalence depending on racial background and genetic polymorphism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cases | diabetic patients suffering from clinically confirmed diabetic retinopathy |
| |
| controls | matched (based on gender and duration of diabetes) diabetic patients free from diabetic retinopathy will be recruited. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SLMAP and EPO genetic polymorphism | Genetic | Presence of EPO gene SNP rs551238 and SLMAP rs17058639 gene polymorphisms |
|
| Measure | Description | Time Frame |
|---|---|---|
| Association of SLMAP gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis | the odds ratio of being diagnosed with diabetic retinopathy in those with SLMAP rs17058639 single nucleotide polymorphism compared to wild type | At baseline (upon confirmed diagnosis of diabetic retinopathy) |
| Association of EPO gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis | The odds ratio of being diagnosed with diabetic retinopathy in those with EPO rs551238 single nucleotide polymorphism compared to wild type | At baseline (upon confirmed diagnosis of diabetic retinopathy) |
| Measure | Description | Time Frame |
|---|---|---|
| The association of confounding factors on the incidence of diabetic retinopathy | A multiple logistic regression model will be fitted to assess the association of diabetic retinopathy to confounders (microalbuminuria, lipid profile, age, gender,...etc.) | At baseline |
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Inclusion Criteria:
Exclusion Criteria:
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All diabetic patients registered to the outpatient clinic of the Endocrinology Unit will be assessed for eligibility followed by screening for diabetic retinopathy by fundoscopic examination Those with diabetic retinopathy will be assigned to the case group while matched diabetic patients free from diabetic retinopathy will be assigned to the control group.
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| Name | Affiliation | Role |
|---|---|---|
| Lamiaa M El Wakeel, PhD | Faculty of Pharmacy, Ain Shams University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University Hospitals | Cairo | Abbasseya | Egypt |
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| ID | Term |
|---|---|
| D003930 | Diabetic Retinopathy |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D003925 | Diabetic Angiopathies |
| D014652 | Vascular Diseases |
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| D002318 |
| Cardiovascular Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |