The Effect of Acute Intermittent Hypoxia on Motor Learning

Examining the Relationship Between Changes in Corticospinal Excitability and Motor Learning After Acute Intermittent Hypoxia in Able-bodied Individuals for Subsequent Study in Individuals With Incomplete Spinal Cord Injury.

The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.

Inclusion Criteria:

• 18 to 70 years old (the latter to reduce likelihood of heart disease);
• Medically stable with medical clearance from physician to participate;
• Motor-incomplete spinal cord injuries at or below C2 and at or above L5;
• AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.);
• More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery;
• Ability to advance one step overground with or without assistive devices;

Exclusion Criteria:

• Severe concurrent illness or pain;
• Recurrent autonomic dysreflexia;
• History of cardiovascular/pulmonary complications;
• Concurrent physical therapy;
• Pregnant at time of enrollment or planning to become pregnant;
• Untreated painful musculoskeletal dysfunction, fracture or pressure sore;
• History of seizures or epilepsy;
• Recurring headaches;
• Concussion within the last six months;
• Depression or manic disorders
• Metal implants in the head, or pacemaker.