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The association between objectively measured physical activity intensities (light, moderate and vigorous), sedentary time and clinical outcomes has not been clarified in patients after a myocardial infarction.
The overall objective of the study is to explore associations between accelerometer measured physical activity and clinical outcomes after a myocardial infarction. Moreover, the association between changes in physical activity and outcomes will be assessed.
It is estimated to include 4000 patients with myocardial infarction during 2 years. Patients will wear the accelerometer for 7 days at follow-up visits (2 months and 1 year) after discharge. The investigators will examine the dose-response relations of several exposure variables from the accelerometer measurements with the outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort group | Diagnosis of a type 1 myocardial infarction registered in SWEDEHEART Age 18-79 years at discharge from hospital |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Accelerometer measurement | Other | Study personnel will initiate an accelerometer and inform the patient to wear the accelerometer with an elastic belt on their right hip during waking hours for seven consecutive days. Moreover, patients are instructed to register their wear time in an activity diary in paper form. In addition, patients will register their working hours, if relevant. After seven days, patients send back the accelerometer and diary in a pre-paid envelope. The same procedure is repeated at the second follow-up visit at 1 year. |
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular event (MACE) | The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure | 1 year after the index cardiac event |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular mortality | Incidence of cardiovascular mortality | 1 year after the index cardiac event |
| Non-fatal myocardial infarction | Incidence of non-fatal myocardial infarction |
| Measure | Description | Time Frame |
|---|---|---|
| Smoking status | 0=Never smoker, 1=Former smoker > 1 month, 2=Smoker | 1 year after the index cardiac event |
| The Swedish Healthy diet questionnaire | Four questions with Likert scale 0-3 points. Higher scores indicate better outcomes |
Inclusion Criteria:
Exclusion Criteria:
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Patients with myocardial infarction will be recruited at the first (2 months after discharge) cardiac rehabilitation follow-up visit at hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maria Bäck, PhD | Contact | +46313421195 | maria.m.back@vgregion.se | |
| Johanna Lilliecrona, MSc | Contact | +46313421195 | johanna.lilliecrona@vgregion.se |
| Name | Affiliation | Role |
|---|---|---|
| Maria Bäck, PhD | Department of physiotherapy, Sahlgrenska University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alingsås lasarett | Recruiting | Alingsås | Sweden |
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| 1 year after the index cardiac event |
| Non-fatal ischemic stroke | Incidence of non-fatal ischemic stroke | 1 year after the index cardiac event |
| Coronary revascularization | Incidence of coronary revascularization | 1 year after the index cardiac event |
| Heart failure | Incidence of hospitalization for new or worsening heart failure | 1 year after the index cardiac event |
| Major adverse cardiovascular event (MACE) | The composite incidence of cardiovascular mortality, non-fatal myocardial infarction, non-fatal ischemic stroke, coronary revascularization, hospitalization for new or worsening heart failure | 3 years after the index cardiac event |
| Cardiovascular mortality | Incidence of cardiovascular mortality | 3 years after the index cardiac event |
| Non-fatal myocardial infarction | Incidence of non-fatal myocardial infarction | 3 years after the index cardiac event |
| Non-fatal ischemic stroke | Incidence of non-fatal ischemic stroke | 3 years after the index cardiac event |
| Coronary revascularization | Incidence of coronary revascularization | 3 years after the index cardiac event |
| Heart failure | Incidence of hospitalization for new or worsening heart failure | 3 years after the index cardiac event |
| All-cause death | Incidence of all-cause death | 1 year after the index cardiac event |
| All-cause death | Incidence of all-cause death | 3 year after the index cardiac event |
| 1 year after the index cardiac event |
| Health-related quality of life (EuroQol- 5 Dimension) | EuroQol- 5 Dimension (EQ-5D-3L) The EQ-5D-3L comprises the following five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 3 levels: no problems, some problems, and extreme problems. Higher scores indicate better outcomes. | 1 year after the index cardiac event |
| Health-related quality of life (EQ visual analogue scale) | EQ visual analogue scale (EQ VAS). The EQ VAS records the respondent's self-rated health on a vertical, visual analogue scale where the endpoints are labelled 'Best imaginable health state' and 'Worst imaginable health state'. | 1 year after the index cardiac event |
| Triglycerides | Plasma levels of triglycerides (mmol/L). Higher values indicate worse outcome. | 1 year after the index cardiac event |
| High-density lipoprotein (HDL) cholesterol | Plasma levels of HDL (mmol/L). Higher values indicate better outcome | 1 year after the index cardiac event |
| Low-density lipoprotein (LDL) cholesterol | Plasma levels of LDL cholesterol (mmol/L). Higher values indicate worse outcome | 1 year after the index cardiac event |
| Hemoglobin A1c (HbA1c) | HbA1c (mmol/L). Measures the amount of blood sugar. Higher values indicate worse outcome | 1 year after the index cardiac event |
| Blood pressure | mmHg | 1 year after the index cardiac event |
| Body weight | kg | 1 year after the index cardiac event |
| Waist circumference | cm | 1 year after the index cardiac event |
| NU-sjukvården Dalslands sjukhus | Recruiting | Bäckefors | Sweden |
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| Bollnäs sjukhus | Recruiting | Bollnäs | Sweden |
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| Höglandssjukhuset Eksjö | Recruiting | Eksjö | Sweden |
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| Lasarettet Enköping | Recruiting | Enköping | Sweden |
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| Gävle sjukhus | Not yet recruiting | Gävle | Sweden |
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| Sahlgrenska University Hospital Sahlgrenska | Recruiting | Gothenburg | Sweden |
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| Helsingborgs lasarett | Recruiting | Helsingborg | Sweden |
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| Jönköping Ryhov Hospital | Recruiting | Jönköping | Sweden |
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| Kalix sjukhus | Recruiting | Kalix | Sweden |
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| Länssjukhuset Kalmar | Recruiting | Kalmar | Sweden |
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| Centralsjukhuset Karlstad | Recruiting | Karlstad | Sweden |
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| Kullbergska sjukhuset | Recruiting | Katrineholm | Sweden |
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| Västmanlands sjukhus Köping | Recruiting | Köping | Sweden |
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| Universitetssjukhuset Linköping | Recruiting | Linköping | Sweden |
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| Sunderby sjukhus | Recruiting | Luleå | Sweden |
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| NU-sjukvården Lysekil | Recruiting | Lysekil | Sweden |
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| Skåne Universitetssjukhus Malmö | Recruiting | Malmö | Sweden |
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| Vrinnevisjukhuset | Withdrawn | Norrköping | Sweden |
| Oskarshamns sjukhus | Recruiting | Oskarshamn | Sweden |
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| Västmanlands sjukhus Sala | Recruiting | Sala | Sweden |
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| Sandvikens sjukhus | Recruiting | Sandviken | Sweden |
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| Capio Närsjukhus Simrishamn | Recruiting | Simrishamn | Sweden |
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| Skaraborgs sjukhus Skövde | Recruiting | Skövde | Sweden |
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| Söderhamns sjukhus | Not yet recruiting | Söderhamn | Sweden |
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| Capio St Göran | Recruiting | Stockholm | Sweden |
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| Karolinska University Hospital Solna and Huddinge | Recruiting | Stockholm | Sweden |
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| Södersjukhuset | Recruiting | Stockholm | Sweden |
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| NU-sjukvården Strömstad | Recruiting | Strömstad | Sweden |
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| Norrlands Universitetssjukhus Umeå | Active, not recruiting | Umeå | Sweden |
| Akademiska sjukhuset | Recruiting | Uppsala | Sweden |
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| Hallands sjukhus Varberg | Recruiting | Varberg | Sweden |
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| Värnamo sjukhus | Recruiting | Värnamo | Sweden |
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| Västerviks sjukhus | Recruiting | Västervik | Sweden |
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| Visby Lasarett | Not yet recruiting | Visby | Sweden |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D001519 | Behavior |
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