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| Name | Class |
|---|---|
| The Administrative Department of Science, Technology and Innovation, Colciencias | OTHER |
| National Center for Research in Chronic Diseases, Colombia | UNKNOWN |
| Johns Hopkins Bloomberg School of Public Health |
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Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them.
The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance.
The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained.
A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| General group | 18-80 years old adults from the Colombian Caribbean Coast. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Genetic risk variants | Genetic | Exposure: Genetic predisposition to complex diseases. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Atherosclerosis | Carotid atheroma identified by eco-doppler imaging test | baseline - 10 years (end of follow up) |
| Acute cardiovascular event | Record of acute coronary heart disease, miocardipathy, and ischemic or hemorragic cerebrovascular event. | 2nd year (first follow up) - 10 years (end of follow up) |
| Chronic airflow obstruction | Obstruction patterns in post-bronchodilator spirometry. | baseline - 10 years (end of follow up) |
| Metabolic syndrome | Pathologic findings for blood pressure, triglycerides, HDLc, serum glucose, and/or enlarged waist circumference (three or more of this criteria found simultaneously) | baseline - 10 years (end of follow up) |
| Measure | Description | Time Frame |
|---|---|---|
| Chronic Obstructive Pulmonary Disease (COPD) | Diagnosis of by lung function test (post-bronchodilator spirometry) and/or clinical criteria | baseline - 10 years (end of follow up) |
| Hypertension |
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Inclusion Criteria:
Exclusion Criteria:
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Adults, men and women, living on Colombian Caribbean Coast.
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| Name | Affiliation | Role |
|---|---|---|
| GUSTAVO J MORA-GARCIA, PhD | Universidad de Cartagena | Principal Investigator |
| VANESSA GARCIA-LARSEN, PhD | BLOOMBERG SCHOOL OF PUBLIC HEALTH JOHNS HOPKINS UNIVERSITY | Study Director |
| MARIA S RUIZ-DIAZ, PhD | NATIONAL CENTER FOR RESEARCH IN CHRONIC DISEASES | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad de Cartagena | Cartagena | Departamento de BolÃvar | 130012 | Colombia |
Documents (i.e., study protocol, informed consent, and laboratory test) and study database are being save on a secure server at https://redcap.unicartagena.edu.co/redcap/
Sharing of study protocol, statistical analysis plan and analytic code is awaiting to be discussed by the research team.
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D012131 | Respiratory Insufficiency |
| D050197 | Atherosclerosis |
| D000073296 | Noncommunicable Diseases |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| ID | Term |
|---|---|
| D004032 | Diet |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D009043 | Motor Activity |
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| Universidad Catolica de Cordoba | UNKNOWN |
| University of Chile | OTHER |
| Universidad de Sucre | UNKNOWN |
| Universidad del Magdalena | OTHER |
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Whole human DNA from blood samples. Microbiome DNA sample from oral-pharyngeal mucose samples.
| Diet |
| Other |
Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases. |
|
| Physical activity | Behavioral | Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior. |
|
| Socio-economic conditions | Other | Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others). |
|
Primary high blood pressure according to clinical criteria
| baseline - 10 years (end of follow up) |
| Type 2 Diabetes Mellitus | Abnormal results in fasting serum glucose test and/or HbA1c test. | baseline - 10 years (end of follow up) |
| Dyslipidemia | High serum cholesterol, triglycerides or LDLc; and/or low HDLc | baseline - 10 years (end of follow up) |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |