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The objective of this project is to evaluate the postprandial serum and plasma vitamin and mineral levels in healthy adult men and women between 18 and 32 years of age, following a single intake of a multivitamin and mineral supplement processed in two different ways.
Serum or plasma levels of five vitamins and four minerals will be measured at baseline, and 1, 2, 4, and 6 hours after the intake of a multivitamin/mineral supplement processed by two different methods. The two methods involve using either conventional isolated vitamins and minerals blended together to provide approximately 100% of the Daily Value, or using the same amount of vitamins and minerals that have first been processing into liposomal forms before blending.
Participants are required to come for two study visits which are 5 to 7 days apart. Health screening will also be done at Study Visit 1. The order of supplement assignment will be randomized, performed in a double-blind manner.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multivitamin/mineral supplement A to B | Experimental | Participants will be randomly assigned to receive Supplement A and after 5-7 days of follow-up, they will receive Supplement B. |
|
| Multivitamin/mineral supplement B to A | Experimental | Participants will be randomly assigned to receive Supplement B and after 5-7 days of follow-up, they will receive Supplement A. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multivitamin/mineral supplement A | Dietary Supplement | Oral administration of Supplement A |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum Vitamin A | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum folate | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum Vitamin D | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum Vitamin B-12 | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of plasma Vitamin C | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum zinc | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum iron | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals |
| Measure | Description | Time Frame |
|---|---|---|
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of Vitamin A (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of folate (mg/dL) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert M. Hackman, PhD | Research Nutritionist | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ragle Human Nutrition Research Center | Davis | California | 95616 | United States |
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| ID | Term |
|---|---|
| C067316 | Geritol |
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Participants will be randomly assigned to receive either supplement A or supplement B during the first visit. Five to seven days later, participants will receive the other supplement.
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| Multivitamin/mineral supplement B | Dietary Supplement | Oral administration of Supplement B |
|
Total area-under-the-curve of serum manganese
| 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Total area-under-the-curve of serum magnesium | 6 hours |
| 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of Vitamin D (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of Vitamin B-12 (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum plasma level of Vitamin C (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of zinc (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of iron (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of manganese (mg/dL) | 6 hours |
| Assess the serum or plasma levels of five vitamins and four minerals | Maximum serum level of magnesium (mg/dL) | 6 hours |