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The activated clotting time (ACT), global thrombosis test (GTT-3), platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous coronary intervention (PCI).
The activated clotting time (ACT), global thrombosis test (GTT-3) and platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous coronary intervention (PCI) - 20 smoking and 20 non-smoking.The measurements will take place: before coronary angiography (CA), 10 minutes after unfractionated heparin (HNF), 2h after CA, 6h after CA, 30 days after CA
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-smoking | Non-smoking patients undergoing coronary angiography or percutaneous coronary intervention | ||
| Smoking | Smoking patients undergoing coronary angiography or percutaneous coronary intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| ACT change | Activated Clotting Time | Baseline ACT , 10 minutes ACT, 2 hours ACT, 6 hours ACT, 30 days ACT |
| GTT-3 change | Global Thrombosis Test | Baseline GTT-3, 10 minutes GTT-3, 2 hours GTT-3, 6 hours GTT-3, 30 days ACT |
| VerifyNow change | Platelet inhibition P2Y12 test | Baseline VerifyNow, 10 minutes VerifyNow, 2 hours VerifyNow, 6 hours VerifyNow, 30 days ACT |
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Inclusion Criteria:
Exclusion Criteria:
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40 patients, 20 smoking at least 10 cigarettes a day, 20 patients non-smoking (<1 cigarette in last 30 days)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bogumił Ramotowski, MD, PhD | Contact | +48604355784 | bram@onet.pl |
| Name | Affiliation | Role |
|---|---|---|
| Bogumił Ramotowski | Centre of Postgraduate Medical Education | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38241058 | Derived | Ramotowski B, Lewandowski P, Slomski T, Maciejewski P, Budaj A. Platelet reactivity and activated clotting time predict hemorrhagic site complications in patients with chronic coronary syndromes undergoing percutaneous coronary interventions. Coron Artery Dis. 2024 Jun 1;35(4):292-298. doi: 10.1097/MCA.0000000000001336. Epub 2024 Jan 22. |
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| ID | Term |
|---|---|
| D012907 | Smoking |
| ID | Term |
|---|---|
| D001519 | Behavior |
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2ml sample of full blood from each patient at baseline 4ml sample of plasma from each patient at each timepoint