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Vitiligo patients on systemic and local therapy may have some ocular adverse effects associated with the disease and its therapy.
Chorioretinal changes associated with vitiligo therapy could address patients visual acuity and life style. Early detection of these changes can help these patients to evade such adverse effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitiligo patients on therapy | Patients diagnosed as vitiligo and on systemic and local therapy. |
| |
| Control group | Normal subjects recruited from ophthalmology clinic and visit the clinic for regular check-up. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optical coherence tomography angiography (OCT-A) | Diagnostic Test | Optical coherence tomography angiography scanning will be done for all subjects in the study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of vessel density (VD) in superficial and deep retinal layer. | Percentage (%) of superficial and deep vessel density changes in both groups measured by OCT-A software to asses retinal ischemia. | Immediately after OCT-A for each eye and at one month of follow-up. |
| Measure | Description | Time Frame |
|---|---|---|
| Foveal avascular zone (FAZ) in millimeter (mm). | Foveal avascular zone measurement in both groups in mm measured by OCT-A software. | Immediately after OCT-A for each eye and at one month of follow-up. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in visual acuity | Visual acuity measurements in decimal form | Immediately after OCT-A for each eye and at one month of follow-up. |
| Changes in choroidal thickness | Choroidal thickness in mm. |
Inclusion Criteria:
Exclusion Criteria:
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Dermatology and ophthalmology clinics at banha university.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Abdelshafy, MD | Contact | 01222328766 | ahmad4lg@gmail.com | |
| Amal Yousif, MD | Contact | 01008128810 | amalderma@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Amal A Yousif, MD | Benha University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Benha University | Recruiting | Banhā | QA | 13511 | Egypt |
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| ID | Term |
|---|---|
| D014820 | Vitiligo |
| D002825 | Chorioretinitis |
| ID | Term |
|---|---|
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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|
| Immediately after OCT-A for each eye and at one month of follow-up. |
| D012173 | Retinitis |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D002833 | Choroiditis |
| D015862 | Choroid Diseases |
| D014603 | Uveal Diseases |
| D015866 | Uveitis, Posterior |
| D015864 | Panuveitis |
| D014605 | Uveitis |