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This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.
A positive family history of hypertension (FHH) (+FHH) is associated with elevated left ventricular mass (LVM). Regular physical activity (PA) may eliminate differences in LVM between +FHH and negative family history of hypertension (-FHH) adults. PURPOSE: To determine if a +FHH is associated with a greater LVM compared to a -FHH group within a sample of young, mostly active healthy adults with and without statistically controlling for PA. METHODS: Healthy young (18-32yrs) participants self-reported FHH status and habitual moderate and vigorous PA frequency. Participants then underwent an echocardiogram.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Positive Family History of Hypertension | Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension. |
| |
| Negative Family History of Hypertension | Young normotensive generally healthy adult with no biological parent with diagnosed hypertension. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Family history of hypertension | Other | Presence or absence of a family history of hypertension in a cross sectional study design. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Left Ventricular Mass | Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound. | Day 2 |
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Inclusion Criteria:
Exclusion Criteria:
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Young healthy normotensive adults who are capable of self reporting family history of hypertension.
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| Name | Affiliation | Role |
|---|---|---|
| Evan L Matthews, PhD | Montclair State University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37158799 | Result | Callaghan KN, Hosick PA, Brian MS, Matthews EL. Impact of a family history of hypertension and physical activity on left ventricular mass. J Sports Med Phys Fitness. 2023 Aug;63(8):949-956. doi: 10.23736/S0022-4707.23.14877-8. Epub 2023 May 9. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Individual Participant Data Set | View IPD |
Individual participant data is available on the Montclair State University Digital Commons website.
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The data is currently available with no expiration date.
Publicly available
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| ID | Title | Description |
|---|---|---|
| FG000 | Positive Family History of Hypertension | Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension. Family history of hypertension: Presence or absence of a family history of hypertension in a cross sectional study design. |
| FG001 | Negative Family History of Hypertension | Young normotensive generally healthy adult with no biological parent with diagnosed hypertension. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Positive Family History of Hypertension | Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension. Family history of hypertension: Presence or absence of a family history of hypertension in a cross sectional study design. |
| BG001 | Negative Family History of Hypertension |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Left Ventricular Mass | Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound. | Posted | Mean | Standard Deviation | gram | Day 2 |
|
3 years, 10 months
There were no adverse events or mortality in this study. This was an observational cross-sectional study with no intervention.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Positive Family History of Hypertension | Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension. Family history of hypertension: Presence or absence of a family history of hypertension in a cross sectional study design. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Evan Matthews, Associate Professor | Montclair State University | 9736553948 | matthewse@montclair.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 14, 2023 | Mar 14, 2023 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D020022 | Genetic Predisposition to Disease |
| ID | Term |
|---|---|
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Complete individual participant data set is publicly available on the Montclair State University Digital Commons. |
Young normotensive generally healthy adult with no biological parent with diagnosed hypertension. |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
| Left Ventricular Mass/Body Surface Area | Mean | Standard Deviation | grams/meter squared |
|
| Units | Counts |
|---|---|
| Participants |
|
|
| 0 |
| 29 |
| 0 |
| 29 |
| 0 |
| 29 |
| EG001 | Negative Family History of Hypertension | Young normotensive generally healthy adult with no biological parent with diagnosed hypertension. | 0 | 32 | 0 | 32 | 0 | 32 |
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