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Corona virus disease has been a pandemic since its beginning. The problem has scaled to break health care system of multiple countries. One of the prime strategy of preventing this disease has been large mass scale vaccination campaign ongoing worldwide. No vaccine has been proven to 100 percent effective in preventing the infection with coronavirus disease so far. The investigators are conducting a study comparing outcome among vaccinated and unvaccinated population admitted to critical care unit of civil services hospital, Kathmandu , Nepal .
Coronavirus disease has been a pandemic since its beginning. The problem has scaled up and health care system of multiple countries have reached to a breaking point . One of the prime strategy of preventing this disease has been large mass scale vaccination campaign ongoing worldwide. No vaccine has been proven to 100 percent effective in preventing the infection with coronavirus disease so far. The investigators are conducting a study comparing difference in outcome with regard to mortality and length of critical care unit stay among vaccinated and unvaccinated population admitted to critical care unit of civil services hospital , Kathmandu , Nepal.
Since different groups of population received different vaccine according to age profession and other factors investigators are trying to study the effectiveness of vaccine with regards to type of vaccine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vaccinated | patient between age 18 and above who have received a complete dose of coronavirus disease vaccine patient who has been admitted to critical care unit due to corona virus disease infection |
| |
| unvaccinated | patients between age 18 and above who has been admitted to critical care unit due to coronavirus disease infection and admitted to critical care unit |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vaccine | Drug | patients who have received vaccine against coronavirus disease infection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | the primary outcome to be measured will be difference in mortality among two groups (vaccinated and unvaccinated) of coronavirus infected patients admitted in critical care unit | within 12 weeks from the date of critical care unit admission |
| length of icu stay | difference in length of stay between vaccinated and unvaccinated population admitted to critical care unit after being infected with coronavirus disease | with 12 weeks from the date of critical care unit admission |
| Measure | Description | Time Frame |
|---|---|---|
| difference in mortality due to associated co-morbidity | difference in mortality due to associated co-morbidity will be compared among both the group (vaccinated and unvaccinated) | within 24 weeks form the date of critical care unit admission |
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Inclusion Criteria:
patients proven to have covid 19 infection patients more than 18 years of age patients admitted to critical care unit
Exclusion Criteria:
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All the patients who had covid 19 infection and have been admitted to critical care unit will be enrolled in the study.
Patient who have received vaccination against covid 19 infection yet are covid positive will be compared with patients who have not received covid 19 infection and have active covid 19 infection
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deepak Bhandari, MD | Contact | +9779851123608 | drbhandari.crc@gmail.com | |
| Aalok Parajuli, mbbs | Contact | +9779841710564 | livethenature1000@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Deepak Bhandari, MD | Civil Services hospital , Kathmandu Nepal | Principal Investigator |
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| ID | Term |
|---|---|
| D018352 | Coronavirus Infections |
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
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| ID | Term |
|---|---|
| D014612 | Vaccines |
| ID | Term |
|---|---|
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| D007239 |
| Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |