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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A01993-38 | Other Identifier | ID-RCB |
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Hearing aids restore efficiently some auditory functions in age-related hearing loss (ARHL or presbycusis) providing to the elderly an access to oral communication and a return to social life. However, a most of the assessments of their efficacy focus on speech recognition. Spatial hearing and localization are anothers important auditory functions merely evaluated.
The purpose of this study is to evaluate the hearing aids benefits for spatial hearing.
The main objective is to evaluate the hearing aids benefits for spatial hearing with a multidisciplinary approach combing psychophysics, and Positron Emission Tomography (PET) brain imaging in a before/after experimental design. The novelty of the proposal is both theoretical and methodological: the team aim is to identify neural correlates of spatial hearing after hearing rehabilitation and evaluate the evolution of spatial hearing abilities once subjects with presbycusis are fitted with hearing aids. The assessment of spatial hearing processing will rely on both a virtual visuo-auditory 3D immersive platform and functional neuroimaging using PET scan. This project will provide crucial elements for understanding and improving the rehabilitation of age-related hearing loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Presbycusis | Experimental | Patients with presbycusis who receive rehabilitation with hearing aids |
|
| Aged control group | Active Comparator | Aged control group: 15 subjects with normal or near-normal hearing thresholds |
|
| Young control group | Active Comparator | Young control group: 15 subjects with normal hearing thresholds |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET examination | Radiation | PET examinations with auditory stimuli such as human voice and environmental sounds. |
|
| Measure | Description | Time Frame |
|---|---|---|
| level of brain activity | level of brain activity (in ml/100g/min) measured in the auditory regions in PET when the subject performs a spatial localization task | Month 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Life quality by Speech, Spatial and Qualities of Hearing (12) | Speech, Spatial and Qualities of Hearing is a questionnaire specific to the quality of hearing. It has 3 sections; speech hearing, spatial hearing and quality of hearing. This questionnaire contains 15 items evaluated on a scale to 0 (not at all) to 10 (perfectly). | Month 12 |
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Inclusion Criteria:
For presbyacusics subjects:
For older people with normal hearing:
For young people with normal hearing:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mathieu MARX, Professor | Contact | 05 61 77 77 04 | +33 | marx.m@chu-toulouse.fr |
| Name | Affiliation | Role |
|---|---|---|
| Mathieu MARX, Professor | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Toulouse | Recruiting | Toulouse | 31059 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24136826 | Background | Strelnikov K, Rouger J, Demonet JF, Lagleyre S, Fraysse B, Deguine O, Barone P. Visual activity predicts auditory recovery from deafness after adult cochlear implantation. Brain. 2013 Dec;136(Pt 12):3682-95. doi: 10.1093/brain/awt274. Epub 2013 Oct 17. | |
| 25997394 | Background | Vannson N, James C, Fraysse B, Strelnikov K, Barone P, Deguine O, Marx M. Quality of life and auditory performance in adults with asymmetric hearing loss. Audiol Neurootol. 2015;20 Suppl 1:38-43. doi: 10.1159/000380746. Epub 2015 May 19. |
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| ID | Term |
|---|---|
| D034381 | Hearing Loss |
| D011304 | Presbycusis |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
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Patient and control
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| Quality of life assessment | Other | quality of life assessment by :
|
|
| Life quality by Speech, Spatial and Qualities of Hearing (6) |
Speech, Spatial and Qualities of Hearing is a questionnaire specific to the quality of hearing. It has 3 sections; speech hearing, spatial hearing and quality of hearing. This questionnaire contains 15 items evaluated on a scale to 0 (not at all) to 10 (perfectly). |
| Month 6 |
| life quality by Hearing Handicap Inventory For The Elderly Screening (12) | Hearing Handicap Inventory For The Elderly Screening contains 10 items to identify the social and emotional difficulties encountered by the subject due to his deafness according to specific situations. It makes it possible to detect the handicap perceived by the person (the higher the score, the greater the perception of the handicap due to hearing loss). | Month 12 |
| life quality by Hearing Handicap Inventory For The Elderly Screening (6) | Hearing Handicap Inventory For The Elderly Screening contains 10 items to identify the social and emotional difficulties encountered by the subject due to his deafness according to specific situations. It makes it possible to detect the handicap perceived by the person (the higher the score, the greater the perception of the handicap due to hearing loss). | Month 6 |
| life quality by Short Form Health Survey (12) | Short Form Health Survey assesses a patient's overall quality of life. It consists of 36 items. | Month 12 |
| life quality by Short Form Health Survey (6) | Short Form Health Survey assesses a patient's overall quality of life. It consists of 36 items. | Month 6 |
| 28623107 | Background | Vannson N, James CJ, Fraysse B, Lescure B, Strelnikov K, Deguine O, Barone P, Marx M. Speech-in-noise perception in unilateral hearing loss: Relation to pure-tone thresholds and brainstem plasticity. Neuropsychologia. 2017 Jul 28;102:135-143. doi: 10.1016/j.neuropsychologia.2017.06.013. Epub 2017 Jun 13. |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006319 | Hearing Loss, Sensorineural |