• Randomized double-blind, placebo-controlled trial on the effects of an oral probiotic intervention with or without a novel ADP-1 toothpaste Objective
• Determine the safety and effectiveness of oral probiotic intervention with or without a novel toothpaste and compare with placebo

Hypotheses:

1. Subjects using oral probiotics will have better oral health than subjects using placebo toothpaste and placebo lozenges.
2. Subjects using oral probiotics and ADP-1 toothpaste will have better oral health than subjects using oral probiotics and regular toothpaste, and subjects using regular toothpaste and placebo lozenges.

Inclusion Criteria:

• Ages 18 to 65 years old
• Fluent in English
• Have mild to moderate gingivitis (i.e., probing depth between 3mm and 5mm)
• Bleeding on probing on 30%+ areas
• Able to perform oral hygiene adequately after formal instructions
• Able to understand and comply with study procedure
• Able to provide written informed consent
• Able to come to Roseman Dental Clinics in South Jordan for a 90-minute pre-screening to determine eligibility
• Able to complete five (90-minute) clinic visits in 2-week intervals

Exclusion Criteria:

• • Probing depths less than 3mm

  • Breastfeeding, pregnant or trying to become pregnant

  • Currently taking or have taken any of the following within 30 days of enrollment:

    • Oral probiotics
    • Antibiotic medications
    • Antifungal medications (e.g., nystatin, clotrimazole, ketoconazole, griseofulvin)
    • Antiseptic medications
    • Immunosuppressant and/or chemotherapeutic medications
    • Medications that could affect gum response measurement (e.g., calcium channel blockers, cyclosporin, anti-seizures like phenytoin and related drugs, anti-inflammatory agents)

  • Frequent alcohol consumption (> 2 drinks per day, or > 8 per week for women, or > 15 per week for men)

  • Use of marijuana (which can cause dry mouth or other conditions) or recreational drugs

  • Use of tobacco products including chewing tobacco and all types of cigarettes (e-cigarettes)

  • Known allergy to any product ingredient (ingredient list provided by USANA)

YES