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To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.
The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Migratory old people with asthma from northern China in Sanya | Migratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| |
| Migratory old people with allergic rhinitis from northern China in Sanya | Migratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| |
| Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya | Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| |
| Migratory old people with atopic dermatitis from northern China in Sanya | Migratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| |
| Children with asthma in Sanya |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Climate and environment in Sanya | Other | Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China. | The asthma, COPD, allergic rhinitis or atopic dermatitis will be diagnosed and assessed through history of diseases and questionnaire.. | 3 year |
| Measure | Description | Time Frame |
|---|---|---|
| Asthma control of migratory old people with asthma. | Quality of life is assessed through questionnaires of "Asthma Control Questionnaire (ACQ) ". | 1-3 year |
| Asthma life quality of migratory old people with asthma. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shijian Liu, Ph.D | Contact | 86-21-38087983 | liushijian@scmc.com.cn |
| Name | Affiliation | Role |
|---|---|---|
| Shijian Liu, Ph.D | Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University | Recruiting | Sanya | Hainan | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31230828 | Result | Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Xu G, Wu S, Wang C, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Zhang B, Xiao D, Wang Z, Chen Z, Bu X, Zhang H, Zhang X, An L, Zhang S, Zhu J, Cao Z, Zhan Q, Yang Y, Liang L, Tong X, Dai H, Cao B, Wu T, Chung KF, He J, Wang C; China Pulmonary Health (CPH) Study Group. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019 Aug 3;394(10196):407-418. doi: 10.1016/S0140-6736(19)31147-X. Epub 2019 Jun 20. | |
| 33120194 |
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Veinal blood
Children with asthma have being exposure to tropical climate and environment in Sanya for years.
|
| Children with allergic rhinitis in Sanya | Children with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years. |
|
| Children with atopic dermatitis in Sanya | Children with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years. |
|
| Children with eczema in Sanya | Children with eczema have being exposure to tropical climate and environment in Sanya for years. |
|
| Children with urticaria in Sanya | Children with urticaria have being exposure to tropical climate and environment in Sanya for years. |
|
| Migratory old people with eczema from northern China in Sanya | Migratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
|
| Migratory old people with urticaria from northern China in Sanya | Migratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
|
Quality of life is assessed through questionnaires of "Asthma Quality of Life Questionnaire (AQLQ)".
| 1-3 year |
| Lung function of migratory old people with asthma or COPD. | Lung function is assessed through simple lung function test using spirometry. | 1-3 year |
| The respiratory function of migratory old people with COPD. | Lung function is assessed through Saint George Respiratory Questionnaire (SGRQ). | 1-3 year |
| Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis. | Veinal blood was extracted to detect allergens. | 1-3 year |
| Inflammatory factors will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis. | Inflammatory factors such as esophageal granulocytes and eosinophils will be detected to assess inflammatory status of the migratory old people. | 1-3 year |
| The change of asthma incidence rate in migratory old people . | Diagnosis and severity grading of asthma is based on the "American Thoracic Society" or the "National Heart, Lung, and Blood Institute guidelines." | 1-3 year |
| Result |
| Xie L, Liu Z, Hao S, Wu Q, Sun L, Luo H, Yu R, Li X, Wu X, Li S. Assessment of knowledge, attitude, and practice towards pulmonary rehabilitation among COPD patients: A multicenter and cross-sectional survey in China. Respir Med. 2020 Nov-Dec;174:106198. doi: 10.1016/j.rmed.2020.106198. Epub 2020 Oct 20. |
| 29731623 | Result | Zhu B, Wang Y, Ming J, Chen W, Zhang L. Disease burden of COPD in China: a systematic review. Int J Chron Obstruct Pulmon Dis. 2018 Apr 27;13:1353-1364. doi: 10.2147/COPD.S161555. eCollection 2018. |
| 26664107 | Result | Ding Y, Xu J, Yao J, Chen Y, He P, Ouyang Y, Niu H, Tian Z, Sun P. The analyses of risk factors for COPD in the Li ethnic group in Hainan, People's Republic of China. Int J Chron Obstruct Pulmon Dis. 2015 Nov 30;10:2593-600. doi: 10.2147/COPD.S86402. eCollection 2015. |
| 34659624 | Result | Garcia-Almaraz R, Reyes-Noriega N, Del-Rio-Navarro BE, Berber A, Navarrete-Rodriguez EM, Ellwood P, Garcia Marcos Alvarez L; GAN Phase I group. Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organ J. 2020 Dec 5;14(1):100492. doi: 10.1016/j.waojou.2020.100492. eCollection 2021 Jan. |
| 26674694 | Result | Pesce G, Bugiani M, Marcon A, Marchetti P, Carosso A, Accordini S, Antonicelli L, Cogliani E, Pirina P, Pocetta G, Spinelli F, Villani S, de Marco R. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy. Sci Total Environ. 2016 Feb 15;544:645-52. doi: 10.1016/j.scitotenv.2015.12.015. Epub 2015 Dec 10. |
| 14982513 | Result | Zanolin ME, Pattaro C, Corsico A, Bugiani M, Carrozzi L, Casali L, Dallari R, Ferrari M, Marinoni A, Migliore E, Olivieri M, Pirina P, Verlato G, Villani S, Marco R; ISAYA Study Group. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: results from the Italian study of asthma in young adults. Allergy. 2004 Mar;59(3):306-14. doi: 10.1046/j.1398-9995.2003.00391.x. |
| 15208377 | Result | Weiland SK, Husing A, Strachan DP, Rzehak P, Pearce N; ISAAC Phase One Study Group. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004 Jul;61(7):609-15. doi: 10.1136/oem.2002.006809. |
| 33750462 | Result | Wang X, Zhuang Y, Chen Y, Wang H, Wang X. Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China. Allergy Asthma Clin Immunol. 2021 Mar 9;17(1):27. doi: 10.1186/s13223-021-00532-7. |
| 23713625 | Result | Su N, Lin J, Chen P, Li J, Wu C, Yin K, Liu C, Chen Y, Zhou X, Yuan Y, Huang X. Evaluation of asthma control and patient's perception of asthma: findings and analysis of a nationwide questionnaire-based survey in China. J Asthma. 2013 Oct;50(8):861-70. doi: 10.3109/02770903.2013.808346. |
| 19210346 | Result | Li J, Sun B, Huang Y, Lin X, Zhao D, Tan G, Wu J, Zhao H, Cao L, Zhong N; China Alliance of Research on Respiratory Allergic Disease. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy. 2009 Jul;64(7):1083-92. doi: 10.1111/j.1398-9995.2009.01967.x. Epub 2009 Feb 11. |
| 25336941 | Result | Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014 Oct 6;9:1101-10. doi: 10.2147/COPD.S54475. eCollection 2014. |
| 27417220 | Result | Kantor R, Silverberg JI. Environmental risk factors and their role in the management of atopic dermatitis. Expert Rev Clin Immunol. 2017 Jan;13(1):15-26. doi: 10.1080/1744666X.2016.1212660. Epub 2016 Jul 28. |
| 27957490 | Result | Wang X, Li LF, Zhao DY, Shen YW. Prevalence and Clinical Features of Atopic Dermatitis in China. Biomed Res Int. 2016;2016:2568301. doi: 10.1155/2016/2568301. Epub 2016 Nov 13. |
| ID | Term |
|---|---|
| D001249 | Asthma |
| D065631 | Rhinitis, Allergic |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D003876 | Dermatitis, Atopic |
| D004485 | Eczema |
| D014581 | Urticaria |
| D001991 | Bronchitis |
| D004646 | Emphysema |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D017445 | Skin Diseases, Vascular |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D002980 | Climate |
| D004777 | Environment |
| ID | Term |
|---|---|
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D001272 | Atmosphere |
| D008685 | Meteorological Concepts |
| D004778 | Environment and Public Health |
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