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| Name | Class |
|---|---|
| Brown University | OTHER |
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This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.
Despite ongoing progress in the understanding of social behavior, little is known about the single-neuronal mechanisms that underlie human social cognition. The investigators will obtain single-neuronal recordings from the prefrontal cortex in participants undergoing clinically planned deep brain stimulation (DBS) electrode placement.
The study population will consist of subjects undergoing planned DBS placement. Prospective participants will be selected for surgery irrespective of their participation in the study. After consenting to the study, the participants will be allowed to withdraw from participation at any time. No control subjects will be used. Instead, each subject will act as their own control based on task performance.
For the study, neuronal recordings will be integrated within planned neurosurgical care and will be obtained from the prefrontal cortex as participants perform a brief behavioral task. During recordings and prior DBS placement, the participants are normally asked to make movements or answer questions based on verbal cues to aid in targeting the correct areas. The participants will be additionally asked to perform a brief linguistic-based task in which scenarios containing social agents are presented to the participants and in which they have to verbally describe/answer questions about them. Following cortical recordings and stimulation, the standard clinical procedure and DBS electrode placement proceeds as planned. The neuronal and behavioral data will then be analyzed off-line.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neurosurgical subjects | Experimental | Subjects undergoing intracranial neurosurgical procedures |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Behavioral testing during neuronal recordings | Behavioral | Participants undergoing clinically planned neurosurgical procedures will undergo single-neuronal recordings as they perform brief behavioral tasks. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of neurons displaying changes in activity related to task events | Neuronal signals will be recorded during performance of a language-based social task over a 15 minute period. A multinomial logistic regression analyses will be used to evaluate for changes in neuronal activity that are associated with social versus non-social task events. Neuronal activity will be measured as the number of spikes recorded during each event, with each event lasting for approximately one second. Significance threshold will be set to p < 0.01. The primary outcome measure will be the proportion of neurons that reach significance threshold and therefore display task-related modulation. | 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of task events that can be correctly predicted from neuronal activity | Neuronal signals will be recorded during performance of a language-based social task over a 15 minute period. Support vector machines will be used to determine whether changes neuronal activity can accurately predict the participants task performance. Neuronal activity will be measured as the number of spikes recorded during each question-answer event, with each event lasting for approximately one second. Significance threshold will be set to p < 0.01. The primary outcome measure will be the percentage of events that are predicted correctly. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ziv Williams, MD | Contact | 6173126534 | zwilliams@mgh.harvard.edu | |
| Yoav Kfir, PhD | Contact | ykfir@mgh.harvard.edu |
| Name | Affiliation | Role |
|---|---|---|
| Ziv Williams, MD | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Recruiting | Boston | Massachusetts | 02114 | United States |
Processed neural data and relevant code will be made publicly available at the end of the study
Processed neural data and relevant code will be made publicly available at the end of the study
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Human subjects undergoing clinically planned neurosurgical procedures
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| 15 minutes |
| Rhode Island Hospital | Not yet recruiting | Providence | Rhode Island | 02903 | United States |
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