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The Diabetes registry for biomarker research Graz is a prospective cohort-study including subjects with type 1 and type 2 diabetes, rare types of diabetes, obesity and dyslipidemia, aiming to collect data, blood and urine samples of all subjects on an annual basis.
Obesity and diabetes represent probably the most challenging threat to public health in the 21st century.
Despite well-controlled established cardiovascular risk factors, the residual risk in subjects with diabetes mellitus is significantly higher than the risk in those without the condition and it is well established that current risk prediction models for cardiovascular disease using established risk factors do not fully explain the future cardiovascular risk.
Therefore, biomarker for better risk stratification are needed, in particular in subjects with diabetes mellitus. Prospective cohorts, meticulously clinically phenotyping subjects, regularly following them and collecting biomarker samples is one key approach for finding new biomarker panels, that are predictive of treatment response and future micro- and macrovascular complications.
The Diabetes registry for Biomarker Research Graz was initiated in November 2015. Subjects with type 1 and type 2 diabetes, rare types of diabetes, obesity or dyslipidemia are recruited in the outpatient clinic for Diabetes, Lipid and Metabolic Disorders at the University Clinic Graz or in the Rehabilitation Center St. Radegund.
As of September 2021, 1250 subjects are recruited. Blood and urine samples samples are collected at baseline and at annual follow up visits as well as data on medical history, diagnoses and medication.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 1 Diabetes | Patients with diagnosed type 1 diabetes mellitus |
| |
| Type 2 Diabetes | Patients with diagnosed type 2 diabetes mellitus |
| |
| Adipositas | Obese patients with a BMI > 30kg/m2 |
| |
| Lipid metabolism disorder | Patients with disorder of lipid metabolism |
| |
| Type 3 Diabetes Mellitus | Patients with diagnosed type 3 diabetes mellitus |
| |
| Maturity onset diabetes of the young (MODY) | Patients with diagnosed MODY |
| |
| Late onset diabetes of the adult (LADA) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | In this registry no intervention is carried out |
|
| Measure | Description | Time Frame |
|---|---|---|
| Biomarker identification | Identification of biomarker panels that allow prediction of future micro- and macrovascular disease and events. Changes of these biomarkers over time in a selected, defined cohort will be reported. | Over entire period of registry (20 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Biomarker validation | Validation of suggested biomarkers in the field of diabetes complications. | Over entire period of registry (20 years) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with different types of diabetes as well as obesity and lipid metabolism disorder are observed in this registry.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Caren Sourij, MD | Contact | caren.sourij@medunigraz.at | ||
| Harald Sourij, MD | Contact | ha.sourij@medunigraz.at |
| Name | Affiliation | Role |
|---|---|---|
| Harald Sourij, MD | Medical University of Graz | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Graz | Recruiting | Graz | 8010 | Austria |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Urinary, plasma and serum samples are collected for future analysis
Patients with diagnosed LADA |
|
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |