To Evaluate Drug Interactions Between XNW3009, Febuxostat, and Colchicine in Patients With Gout

A Single-center, Open-access Study to Evaluate Drug Interactions Between XNW3009, Febuxostat, and Colchicine in Patients With Gout

A single-center, open-access study to evaluate drug interactions between XNW3009, febuxostat, and colchicine in patients with gout

Inclusion Criteria:

• Subject has a body mass index ≥18.0 and ≤32 kg/m2;
• Screening sUA value ≥480μmol/L;
• Subject has no clinically relevant abnormalities in vital signs, ECG, physical examination，imaging examination or safety laboratory values.

Exclusion Criteria:

• Subject known or suspected of being sensitive to the study drugs or its ingredient；sCr>ULN；
• History of kidney stones or screening kidney stones by B-ultrasound;
• History of malignancy；
• History of xanthinuria；
• Donated blood（≥400ml）within 3 months prior to screening or received transfusion of blood
• ALT or AST > 1.5 x ULN
• Unstable angina, history of symptomatic arrhythmia, or heart failure
• HbAlc>8%
• eGFR<60ml/min/1.73m2
• Investigational drug within 3 months of study dosing