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The purpose of this study is to compare the post-operative course in patients suffering from sarcopenia who had colorectal surgery for cancer. Our primary outcome is the comparaison of the length of hospital stay in sarcopenic and non sarcopenic patients.
Sarcopenia is the loss of muscle mass that occurs usually with aging, but it may have multiple contributing factors, especially related to chronic diseases such as colorectal cancer.
When present, sarcopenia is predictive of poor post-operative course. The identification of sarcopenia needs either the identification of low muscle strength, low muscle quantity/quality, or finally a low physical performance.
Multiple clinical, biological or radiological tools were proposed. Our purpose is to compare the post-operative outcome of sarcopenic and non sarcopenic patients using a simple, available, reproducible and rapid radiological method, which will help the healthcare professionals to rapidly identify high risk patients for possible complicated and long post-operative course allowing them to take appropriate perioperative measures to reduce the risks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Colectomy with anastomosis of any type | Patient with colonic resection followed by ileocolic, or colo colic, or colorectal, or coloanal anastomosis for cancer by laparoscopy or laparotomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Colectomy with anastomosis of any type | Other | Patient with colonic resection followed by ileocolic, or colo colic, or colorectal, or coloanal anastomosis for cancer by laparoscopy or laparotomy |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of the average postoperative length of stay in sacopenic and non-sarcopenic patients | Comparison of the number of post-operative hospital days between the two groups | Until discharge from hospital, an average of 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison between complication rate in sarcopenic and non sarcopenic patients | Measurement of the complication rate according to the Clavien Dindo score (relevant score if greater than or equal to 2, considered severe complication if greater than or equal to 3) between the two groups | At the end of the 30 post-operative days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients suffering from sarcopenia who had colorectal surgery for cancer.
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| Name | Affiliation | Role |
|---|---|---|
| Hicham El Masri | Hospital René Dubos | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier René Dubos | Pontoise | 95300 | France |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D003082 | Colectomy |
| ID | Term |
|---|---|
| D000099090 | Surgical Procedures, Colorectal |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| Assessment of re-hospitalization rate between sarcopenic and non sarcopenic patients |
Evaluation of the number of hospitalizations of more than 24 hours at 30 days after the operation between the two groups |
| At the end of the 30 post-operative days |
| Comparison of the transfer rate to rehabilitation or nursing home center between sarcopenic and non sarcopenic patients | Evaluation of the number of transfer to rehabilitation or nursing home center at 30 days after the operation between the two groups | At the end of the 30 post-operative days |
| Comparison of the length of stay in the rehabilitation center for sarcopenic and non sarcopenic transferred patients | Comparison of the number of hospital days for transferred patients between the two groups | At the end of the 30 post-operative days |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |