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Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular events, although the underlying mechanism remains unclear. This study evaluated the relationship between Lp(a) and high-risk attributes (HRA) by coronary computed tomography angiography (CCTA) as well as their prognostic value.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Patients with Lp(a) <60mg/dL |
| |
| Group 2 | Patients with Lp(a) ≥60 mg/dL |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronary CTA | Diagnostic Test | Patients receive coroanry CTA at the discretion of the physicians in charge. And parameters including plaque burden, minimal lumen area, diameter stenosis, total plaque volume, high-risk plaque characteristics, fractional flow reserve, pullback pressure gradient, fat attenuation index will be analyzed. |
| Measure | Description | Time Frame |
|---|---|---|
| Association of Lp(a) level with CCTA measured Parameters | Association of Lp(a) level with CCTA measured total plaque volume | at the index procedure |
| Association of Lp(a) level with CCTA measured Parameters | Association of Lp(a) level with CCTA measured fractional flow reserve | at the index procedure |
| Association of Lp(a) level with CCTA measured Parameters | Association of Lp(a) level with CCTA measured pullback pressure gradient | at the index procedure |
| Association of Lp(a) level with CCTA measured Parameters | Association of Lp(a) level with CCTA measured fat attenuation index | at the index procedure |
| Association of Lp(a) level with CCTA measured Parameters | Association of Lp(a) level with CCTA measured high-risk plaque characteristics | at the index procedure |
| Major adverse cardiac events | a composite of cardiac death, any myocardial infarction, and stroke | at 24 months from index procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac death | Cardiac death | at 24 months from index procedure |
| Myocardial infarction | Myocardial infarction | at 24 months from index procedure |
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Inclusion Criteria:
Exclusion Criteria:
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Stable CAD patients with serum Lp(a) measured and underwent CCTA within 1 week at Zhongshan Hospital, Fudan University
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Neng Dai, MD | Contact | +8613701997266 | niceday1987@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Junbo Ge, Professor | Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Zhongshan Hospital | Recruiting | Shanghai | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33541549 | Background | Dai N, Hwang D, Lee JM, Zhang J, Jeon KH, Paeng JC, Cheon GJ, Koo BK, Ge J. Feasibility of Quantitative Flow Ratio-Derived Pullback Pressure Gradient Index and Its Impact on Diagnostic Performance. JACC Cardiovasc Interv. 2021 Feb 8;14(3):353-355. doi: 10.1016/j.jcin.2020.10.036. No abstract available. | |
| 34412795 | Background |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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|
| Stroke | stroke | at 24 months from index procedure |
| Shin D, Dai N, Lee SH, Choi KH, Lefieux A, Molony D, Hwang D, Kim HK, Jeon KH, Lee HJ, Jang HJ, Ha SJ, Park TK, Yang JH, Song YB, Hahn JY, Choi SH, Doh JH, Shin ES, Nam CW, Koo BK, Gwon HC, Ge J, Lee JM. Physiological Distribution and Local Severity of Coronary Artery Disease and Outcomes After Percutaneous Coronary Intervention. JACC Cardiovasc Interv. 2021 Aug 23;14(16):1771-1785. doi: 10.1016/j.jcin.2021.06.013. |
| 36503252 | Derived | Dai N, Chen Z, Zhou F, Zhou Y, Hu N, Duan S, Wang W, Yu Y, Zhang L, Qian J, Ge J. Association of Lipoprotein (a) With Coronary-Computed Tomography Angiography-Assessed High-Risk Coronary Disease Attributes and Cardiovascular Outcomes. Circ Cardiovasc Imaging. 2022 Dec;15(12):e014611. doi: 10.1161/CIRCIMAGING.122.014611. Epub 2022 Dec 12. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |