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L-Carnitine supplementation has been shown to boost muscular performance in several studies. In hemodialysis patients with muscular weakness, fatigue, or cramps/aches, after L-carnitine treatment, about two-thirds of patients had at least some improvement in muscular symptoms . L-Carnitine was also found to improve the left ventricular ejection fraction (LVEF) in hemodialysis patients with cardiac morbidity who had significantly reduced LVEF in echocardiography before supplementation. Moreover, L-Carnitine has been shown to improve muscular function and exercise performance in athletes in several studies
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Other | maintenance dose of L- carnitine 6 gm/day to keep normal level (normal L-carnitine level is normal 25-50 mmol/L) |
|
| experimental group | Experimental | high dose of L- Carnitine 18 gm/day as a continuous intravenous infusion to reach double the normal plasma level. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L Carnitine ( low dose) | Drug | will receive a maintenance dose of L- carnitine 6 gm/day to keep normal level (normal L-carnitine level is normal 25-50 mmol/L) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ultrasound diaphragmatic function | Diaphragmatic excursion by ultrasound | at days 7 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine | Cairo | 1234 | Egypt | |||
| Mona A Ammar |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D002331 | Carnitine |
| ID | Term |
|---|---|
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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| L-Carnitine ( high dose) | Drug | will receive a high dose of L- Carnitine 18 gm/day as a continuous intravenous infusion to reach double the normal plasma level |
|
| Cairo |
| Egypt |