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| ID | Type | Description | Link |
|---|---|---|---|
| 13955 | Other Identifier | HiREB |
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| Name | Class |
|---|---|
| Khon Kaen University | OTHER |
| Global Alliance for Chronic Diseases (GACD) | OTHER |
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
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Liver cancer, specifically cholangiocarcinoma (CCA), is very common in different areas in Thailand. Many factors make this cancer more common, such as liver fluke infection, older age, eating raw fish, family history of cancer, alcohol intake, taking certain medicines (praziquantel), low intake of fresh vegetable, and low education. In 2015, researchers from Khon Kaen University developed the Community-based Health Education and Communication (CHEC) program to prevent liver cancer caused by liver flukes in communities of the Khon Kaen province, Thailand.
The main aim of this 5-year research study is to enhance the CHEC program to prevent liver cancer, and test if it is effective in improving the knowledge and behaviours of community residents regarding how to prevent liver cancer. This study will take place in Khon Kaen, Thailand. Other aims are to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual Care Community | No Intervention | Participants in this arm will not be given the eCHEC program | |
| eCHEC Community | Active Comparator | Participants in this arm will be given the eCHEC program as their intervention |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| eCHEC program | Behavioral | The eCHEC program is the enhanced Community-based Health Education and Communication (CHEC) model to prevent O. viverrini in an effort to decrease cholangiocarcinoma (CCA) in Khon Kaen, Thailand |
| Measure | Description | Time Frame |
|---|---|---|
| Intake of raw fish | Mean difference in the self-reported frequency of intake of raw fish in the intervention group compared to the control group. Self reported, pre- and post- intervention. | 12 months |
| Intake of fruits and vegetables | Mean difference in the self-reported frequency of intake of fruits and vegetables in the intervention group compared to the control group. Self reported, pre- and post- intervention. | 12 months |
| Smoking | Difference in the proportion of smoking habits in the intervention group compared to the control group. Self reported, pre- and post- intervention. | 12 months |
| Alcoholic beverage intake | Mean difference in the intake of alcoholic beverages in the intervention group compared to the control group. Self reported, pre- and post- intervention. | 12 months |
| Praziquantel use | Difference in the proportion of use of the medication praziquantel (prescribed or self-medicated) in the intervention group compared to the control group. Self reported, pre- and post- intervention. | 12 months |
| Stool test (proportion of stool test concentration) | Difference in the proportion of positive stool test of concentration of O. viverrini, pre- and post-intervention. | 12 months |
| Stool test (mean concentration) |
| Measure | Description | Time Frame |
|---|---|---|
| Knowledge of preventative measures against CCA | Mean difference in knowledge score about in knowledge of preventative measures against CCA in the intervention group compared to the control group. Measured in questions included in the community survey. | 12 months |
| BMI |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ricardo Angeles, MD, MPH, MHPEd, PhD | Contact | 905-515-2100 | 21203 | angelesric@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gina Agarwal, MBBS, PhD | McMaster University | Principal Investigator |
| Pattapong Kessomboon, MD, PhD | Khon Kaen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Khon Kaen University | Recruiting | Phu Wiang | Changwat Khon Kaen | 40002 | Thailand |
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| ID | Term |
|---|---|
| D018281 | Cholangiocarcinoma |
| D009889 | Opisthorchiasis |
| D006266 | Health Education |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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Difference in the mean concentration of O. viverrini in the stool test, pre- and post-intervention.
| 12 months |
| Stages of change for risk behaviours affecting the development of CCA. | Mean difference in the stages of change for risk behaviours in the intervention group compared to the control group. Self reported, pre- and post- intervention. | 12 months |
Cardiobolic measure linked to developing cancer. Change in the mean body mass index calculated from height and weight (self-reported). |
| 12 months |
| Waist circumference | Cardiobolic measure linked to developing cancer. Change in the mean waist circumference (measured with measuring tape) | 12 months |
| Blood pressure | Cardiobolic measure linked to developing cancer. Change in the mean measured blood pressure (automated, validated device) | 12 months |
| Health literacy | Mean difference in health literacy knowledge score in the intervention group compared to the control group. Self reported, pre- and post- intervention | 12 months |
| Quality of life | Mean difference in quality of life in the intervention group compared to the control group. Self reported, pre- and post- intervention. Using the EuroQol-5 dimension-5 level (EQ-5D-5L) tool | 12 months |
| D009369 | Neoplasms |
| D014201 | Trematode Infections |
| D006373 | Helminthiasis |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000099060 | Adherence Interventions |
| D055118 | Medication Adherence |
| D010349 | Patient Compliance |
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |