Comparison of Triggers in Double Ovarian Stimulation (DuoStim).

Double Ovarian Stimulation (DuoStim) Comparison of Triggers: Is There Any Advantage Using 3 Different Methods of Trigger for the Second Egg Collection in Predicted Low Responders?

This study aims to investigate the efficacy of 3 different trigggers used for final maturation in the second ovarian stimulation in double stimulation protocol (aGnRH and hCG-rec vs. aGnRH only vs. hCG-rec only). The main objective is to compare the number of all retrieved oocytes and mature oocytes in patients predicted to be low ovarian responders.

This is a controlled randomized clinical study where 165 patients will be recruited.

Inclusion Criteria:

• BMI below 32
• Presence of both ovaries
• Indication for ovarian stimulation under Double Stimulation protocol (Duo Stim)
• Meeting the criteria for Duo Stim
• Medical history, history and physical examination without alterations
• AMH and AFV results in accordnace to Poseidon classification group 3 or 4 no more than 6 months prior to signing the consent form
• Ability to participate and comply with the study protocol.
• To have given written consent
• Normal karyotype and fragile X.

Exclusion Criteria:

• Non-compliance with instructions and/or non-formalization of consents or legal requirements for IVF.
• Concurrent participation in another study