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we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation
Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar & salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction.
However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oral Rehydration Salts Power (iii) | Experimental | Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation. |
|
| water with white granulated sugar | Experimental | Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation. |
|
| recommended water intake | Placebo Comparator | Recommend the subjects to drink up 500ml water in 20 minutes prior to donation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral Rehydration Salts power (iii) | Drug | Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation. |
| Measure | Description | Time Frame |
|---|---|---|
| vasovagal reaction rate | vasovagal reaction rate in three groups | 1-3days |
| Measure | Description | Time Frame |
|---|---|---|
| rate of willingness to donate blood again | rate of willingness to donate blood again in three groups | 3days |
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Inclusion Criteria:All blood donors donated whole blood in Guangzhou Blood Center during study.
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Exclusion Criteria:Blood donors who were deferral by blood screening result and other situations.
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| Name | Affiliation | Role |
|---|---|---|
| Guiyun Xie, MPH | Guangzhou Blood Center | Study Chair |
| Jinyan Chen, MPH | Guangzhou Blood Center | Principal Investigator |
| Shijie Li | Guangzhou Blood Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou Blood Center | Guangzhou | Guangdong | 510095 | China |
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| ID | Term |
|---|---|
| D014867 | Water |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 |
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|
| water with white granulated sugar | Dietary Supplement | Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation. |
|
| water | Dietary Supplement | Recommend the subjects to drink up 500ml water in 20 minutes prior to donation. |
|
| Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |