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Comparison between effects of ultrasound guided platelet rich plasma injection versus steroids injection for pain relief in cases of partial rotator cuff tears
The effect of injection of platelet rich plasma will be compared with effects of steroids injection according to pain relief effects,, Side effects ,, healing ability ,, recurrence in both groups.
30 patient in each group will be included
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Platelet rich plasma group | Experimental | participants will receive Ultrasound guided subacromial injection of 3 ml platelet rich plasma+0.5 ml of PRP activator (10% calcium gluconate)+ 1ml 0.5%bupivacaine. |
|
| Methylprednisolone group | Experimental | participants will receive Ultrasound guided subacromial injection of 1 ml methylprednisolone+ 1ml 0.5%bupivacaine + 2.5 ml normal saline. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet rich plasma | Combination Product | platelet rich plasma will be obtained from the particepants own blood mixed with activator and bupivacaine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Shoulder pain assesment | The pain will be assessed using visual analogue scale( score range=0-10,less than 4,4-6 and more than 6 for mild, moderate and severe pain respectively) | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Assesment of rotator cuff tendon healing | assesment healing process of tendon using ultrasound technique | 4 months |
| Assesment the failure rate after shoulder joint injection | failure of relief the symptoms after shoulder joint injection will be recorded |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement plasma C-Reactive Protein level | The plasma C- Reactive Protein level will be measured prior to injection and 4 months later on after the procedure | 4 months |
| Measurement the fasting blood glucose level |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dorreya Fikry | AlexandriaUniversity | Principal Investigator |
| Tarek Sarhan | AlexandriaUniversity | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Facility of medicine | Alexandria | 21519 | Egypt |
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| ID | Term |
|---|---|
| D020069 | Shoulder Pain |
| ID | Term |
|---|---|
| D018771 | Arthralgia |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D008775 | Methylprednisolone |
| ID | Term |
|---|---|
| D011239 | Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
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2 groups will be included
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|
| Methylprednisolone | Combination Product | 1ml methyl prednisolone 40mg\ml mixed with normal saline and bupivacaine |
|
|
| 4 months |
| The reinjection rate recording | the incidence of reinjection the shoulder joint due to inadequate pain relief will be recorded | 4 months |
| Assesment the rate of tear recurrence after shoulder joint injection | The rate of tear recurrence after 4 months of injection will be assessed using MRI or US | 4 months |
| Simple shoulder assessment test | Functional assessment of shoulder joint will be done using simple sholder assessment test 0= maximal disability 20% -40% = crippled 40% -60% = severe disability 60% -80% = moderate disability 100% = no disability | 4 months |
The fasting blood glucose level will be measure prior to and one week later after injection
| one week |
| Assesment the complications after shoulder joint injection | Complications that might occur after shoulder joint injection such as infection, elevated blood sugar, allergy, nerve injury, nausea and vomiting will be recorded | 4 months |
| Measurement the serum cortisol level | Early morning(8 am serum cortisol level) will be measured before the injection and one week later after injection | one week |
| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013256 |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |