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| Name | Class |
|---|---|
| Ottawa Heart Institute Research Corporation | OTHER |
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Left ventricular ejection fraction (LVEF) is one of the strongest predictors of mortality and morbidity in patients with acute coronary syndrome (ACS). Transthoracic echocardiography (TTE) remains the gold standard for LVEF measurement. Currently, LVEF can be estimated at the time of the coronary angiogram but requires a ventriculography. This latter is performed at the price of an increased amount of contrast media injected and puts the patients at risk for mechanical complications, ventricular arrhythmia or atrio-ventricular blocks. Artificial intelligence (AI) has previously been shown to be an accurate method for determining LVEF using different data sources. Fur the purpose of this study, we aim at validating prospectively an AI algorithm, called CathEF, for the prediction of real-time LVEF (AI-LVEF) compared to TTE-LVEF and ventriculography in patients undergoing coronary angiogram for ACS.
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| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve-Receiver Operating Characteristics (AUC-ROC) of the CathEF algorithm for differentiating a LVEF ≤ or >50%, compared to TTE-LVEF | Either 7 days before or up to 7 days after the coronary angiogram |
| Measure | Description | Time Frame |
|---|---|---|
| Comparing AUC-ROC of CathEF and ventriculography for differentiating a LVEF ≤ or >50% | Either 7 days before or up to 7 days after the coronary angiogram | |
| Sensitivity of CathEF and ventriculography for differentiating a LVEF ≤ or >50% in comparison to TTE-LVEF. |
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Inclusion Criteria:
Exclusion Criteria:
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All adults treated by percutaneous coronary intervention for ACS in whom left ventriculography is not contra-indicated and TTE-LVEF is expected to be measured in the next 24h to 7 days.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Robert Avram | Montreal | Quebec | H1T1C8 | Canada |
Data will be shared to other researchers on reasonable request to the principal investigator.
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| D018487 | Ventricular Dysfunction, Left |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| Either 7 days before or up to 7 days after the coronary angiogram |
| Specificity of CathEF and ventriculography for differentiating a LVEF ≤ or >50% in comparison to TTE-LVEF. | Either 7 days before or up to 7 days after the coronary angiogram |
| Number of participants with major adverse cardiovascular events (Combined outcome of combined outcomeof mortality, ventricular arrhythmia requiring an intervention, heart failure, need for inotropic support, renal failure KDIGO≥2 and stroke) | At 7 days or before discharge, if earlier. |
| AUC-ROC of the re-trained CathEF algorthim for differentiating a LEVF ≤ or >50% | Either 7 days before or up to 7 days after the coronary angiogram |
| Sensitivity of the re-trained CathEF algorthim for differentiating a LEVF ≤ or >50% | Either 7 days before or up to 7 days after the coronary angiogram |
| Specificity of the re-trained CathEF algorthim for differentiating a LEVF ≤ or >50% | Either 7 days before or up to 7 days after the coronary angiogram |
| Likert scale on the impact on the procedure, ease of use and utility of the CathEF algorithm in the clinical practice, as assessed by interventional cardiologists | Through study completion, an average of 1 year. |
| D018754 |
| Ventricular Dysfunction |