A Study of the Use of Acellular Dermal Matrix for Breast Reconstruction

A Randomized Controlled Trial of Prepectoral Breast Reconstruction With and Without Acellular Dermal Matrix

The researchers are doing this study to look at the number of complications that occur immediately after prepectoral breast reconstruction when Acellular Dermal Matrix (ADM) is used compared to when ADM is not used. These complications include infections, the need for Tissue Expander (TE) or implant removal, and other conditions that lead to additional surgery.

Inclusion Criteria:

• Females aged 21-60 years
• Planning to undergo unilateral or bilateral mastectomy, prophylactically or to treat breast cancer
• Planning to undergo immediate two-stage prosthetic breast reconstruction with TE placement as the first stage
• Planning to undergo nipple-sparing or skin-sparing mastectomy
• Adequate mastectomy skin perfusion or adequate perfusion but nonviable mastectomy skin that can be excised (≤4 cm) at the defect margins with otherwise adequate perfusion
• Intraoperative confirmation of prepectoral plane viability by operating physician

Exclusion Criteria:

• History of radiotherapy to the operative breast
• Current smoker
• Non-English speaking patients
• Planning to undergo direct-to-implant reconstruction
• Prior sternotomy