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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A02341-40 | Other Identifier | ANSM |
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As part of the preparation at the Paris 2024 Olympic Games, the French rowing and cycling federations and a consortium of researchers met to reach an ultimate goal: to increase the number of medals in these two disciplines for Paris 2024 Olympics.
The objective of this study is to evaluate the maximum capacity of power production of athletes by describing their power-endurance profile and the physiological factors underlying this maximum power generation capacity. These assessments will guide coaches and athletes for:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Track cyclists and rowers (males and females) | Experimental | All female and male rowing and track cycling athletes at the national or international national or international level, registered in a selection process and likely to represent France at the likely to represent France at the 2024 Olympics will be asked to take part to take part in this study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypoxia | Other | Subjects will be subjected to mild hypoxia simulating an altitude of 1750 m (normobaric hypoxia). Hypoxia decreases oxygen supply to tissue and limit exercise capacity. For this, the subjects will inhale a gas mixture depleted in oxygen (enriched in nitrogen). The barometric pressure at 1500 m being 621 mmHg, PIO2 at this altitude (PIO2 = (621 - 47) x 21%) is 120.5 mmHg. For sea level altitude where the barometric pressure is 760 mmHg, the hypoxic gas mixture should contain (x = 120.5 / (760 - 47)) 16.8% O2. Thus, by inhaling a gas mixture that is oxygen-depleted from 21 to 16.8%, subjects (will simulate the altitude of 1750 and) will experience the equivalent of a 20% reduction in oxygen supply. |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum force produced at zero speed in a fatigue-free condition | F0i measurement | Month : 3 |
| Speed in a fatigue-free condition | V0i measurement | Month : 3 |
| Maximum force produced at zero speed at the end of the 3 min. | F0e measurement | Month : 3 |
| Speed up produced at the end of the 3 min. | V0e measurement | Month : 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal oxygen uptake (VO2max) | Cardiac stress test | At inclusion |
| Maximal Ventilation (VEmax) | Cardiac stress test | At inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Léonard FEASSON, PhD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Laurent MESSONNIER, PhD | Université Savoie Mont Blanc, CHAMBERY | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CEPART | Le Bourget-du-Lac | 73370 | France | |||
| Chu Nantes |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40605256 | Derived | Blervaque L, Merlet AN, Maciejewski H, Feasson L, Messonnier LA. Capillary-to-sarcolemma distance and location of cytochrome c oxidase: Insights for maximal O2 uptake and muscle lactate release in trained athletes. J Physiol. 2025 Jul;603(14):3945-3960. doi: 10.1113/JP288318. Epub 2025 Jul 2. |
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| ID | Term |
|---|---|
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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This is a prospective multi-center exploratory pilot study of physiology study on athletes, track cyclists or rowers national to international level competitors.
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| Cardiac output (QCmax) | Cardiac stress test | At inclusion |
| Maximal cardiac frequency (fcmax) | Cardiac stress test | At inclusion |
| Fibre type determination | Muscle biopsy of the vastus lateralis | Month : 2 |
| Microvasculature analysis | Muscle biopsy of the vastus lateralis | Month : 2 |
| Muscle enzyme activity (Phosphofructokinase (PFK), lactate dehydrogenase (LDH), citrate synthase (CS) et cyclo-oxygenase (COx)) | Muscle biopsy of the vastus lateralis | Month : 2 |
| Maximal voluntary force (N) | Comparison before and after exercise | Month : 9 |
| Rate of force development | Comparison of force development | Month : 9 |
| Evoked forces (N) | Ratio of evoked force at low and high frequencies | Month : 9 |
| Maximum force produced at zero speed in a fatigue-free condition after bicarbonate ingestion | F0i measurement | Month : 3 |
| Speed in a fatigue-free condition after bicarbonate ingestion | V0i measurement | Month : 3 |
| Maximum force produced at zero speed at the end of the 3 min after bicarbonate ingestion | F0e measurement | Month : 3 |
| Speed up produced at the end of the 3 min after bicarbonate ingestion | V0i measurement | Month : 3 |
| Maximal oxygen uptake (VO2max) after bicarbonate ingestion | Cardiac stress test | At inclusion |
| Maximal Ventilation (VEmax) after bicarbonate ingestion | Cardiac stress test | At inclusion |
| Cardiac output (QCmax) after bicarbonate ingestion | Cardiac stress test | At inclusion |
| Maximal cardiac frequency (fcmax) after bicarbonate ingestion | Cardiac stress test | At inclusion |
| Fibre type determination after bicarbonate ingestion | Muscle biopsy of the vastus lateralis | Month : 2 |
| Microvasculature analysis after bicarbonate ingestion | Muscle biopsy of the vastus lateralis | Month : 2 |
| Muscle enzyme activity (Phosphofructokinase (PFK), lactate dehydrogenase (LDH), citrate synthase (CS) et cyclo-oxygenase (COx)) after bicarbonate ingestion | Muscle biopsy of the vastus lateralis | Month : 2 |
| Maximal voluntary force (N) after bicarbonate ingestion | Comparison before and after exercise | Month : 9 |
| Rate of force development after bicarbonate ingestion | Comparison of force development | Month : 9 |
| Evoked forces (N) after bicarbonate ingestion | Ratio of evoked force at low and high frequencies | Month : 9 |
| Nantes |
| 44000 |
| France |
| Chu Saint-Etienne | Saint-Etienne | 42055 | France |