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The diagnostic value of Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and Proinflammatory cytokines (TNF-a and interleukin-6) in ovarian endometriosis and deep infiltrating endometriosis, their levels in organ-specific involvement, their relationship with symptoms, and the changes of these markers in the postoperative period will be evaluated.
Serum Annexin V, sVCAM-1, sICAM-1, vascular endothelial growth factor and proinflammatory cytokines (TNF-a and interleukin-6) values were studied by taking blood samples from all patients before and three months after the operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Group | Stage 3 and 4 endometriosis patients |
| |
| Control Group | Patients without endometriosis, who required surgery for tubal ligation, benign ovarian cysts or uterine fibroids were included. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endometriosis surgery | Procedure | Laparoscopy was performed in the follicular phase of the woman's menstrual cycle and all recognizable endometriotic lesions were treated by bipolar coagulation, resection of endometriotic nodules and ovarian cystectomy. |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic value of serum Annexin V in endometriosis | To determine whether serum Annexin V levels (ng/mL) can be used as diagnostic markers of endometriosis disease. | Up to 4 months |
| Diagnostic value of serum sVCAM-1 in endometriosis | To determine whether serum sVCAM-1(ng/mL) levels can be used as diagnostic markers of endometriosis disease. | Up to 4 months |
| Diagnostic value of serum sICAM-1 in endometriosis | To determine whether serum sICAM-1(ng/mL) levels can be used as diagnostic markers of endometriosis disease. | Up to 4 months |
| Diagnostic value of serum Vascular Endothelial Growth Factor in endometriosis | To determine whether serum Vascular Endothelial Growth Factor (pg/mL) levels can be used as diagnostic markers of endometriosis disease. | Up to 4 months |
| Diagnostic value of serum TNF-alpha in endometriosis | To determine whether serum TNF-alpha (pg/mL) levels can be used as diagnostic markers of endometriosis disease. | Up to 4 months |
| Diagnostic value of serum Interleukin-6 in endometriosis | To determine whether serum Interleukin-6 (pg/mL) levels can be used as diagnostic markers of endometriosis disease. | Up to 4 months |
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Inclusion Criteria:
1. Stage III and IV endometriosis patients requiring surgery due to chronic pelvic pain or suspected malignancy
Exclusion Criteria:
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Stage III and IV endometriosis patients aged 18-50 years requiring surgery for chronic pelvic pain or suspected malignancy
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| Name | Affiliation | Role |
|---|---|---|
| Evrim Ebru Kovalak, MD | Bagcilar Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bagcilar Teaching and Research Hospital | Istanbul | Bagcilar | 34200 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22736326 | Result | Vodolazkaia A, El-Aalamat Y, Popovic D, Mihalyi A, Bossuyt X, Kyama CM, Fassbender A, Bokor A, Schols D, Huskens D, Meuleman C, Peeraer K, Tomassetti C, Gevaert O, Waelkens E, Kasran A, De Moor B, D'Hooghe TM. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis. Hum Reprod. 2012 Sep;27(9):2698-711. doi: 10.1093/humrep/des234. Epub 2012 Jun 26. |
| Label | URL |
|---|---|
| Based on the above publication | View source |
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| other benign condition surgeries | Procedure | ovarian cystectomy, bilateral tubal ligation, myomectomy etc. |
|
| D000091662 | Genital Diseases |