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To assess the efficacy of Wasabi Leaf Extract on skin
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo drink | Placebo Comparator |
| |
| Wasabi Leaf Extract Drink | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo drink | Dietary Supplement | consume 1 bottle per day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin melanin index | Mexameter® MX18 was utilized to measure skin melanin index. Units: arbitrary Mexameter® units (0-999) | Change from Baseline skin melanin index at 8 weeks |
| The change of skin erythema index | Mexameter® MX18 was utilized to measure skin erythema index. Units: arbitrary Mexameter® units (0-999) | Change from Baseline skin erythema index at 8 weeks |
| The change of skin sebum content | Sebumeter® SM815 was utilized to measure skin sebum content. Units: Sebumeter® units from 0-350 | Change from Baseline skin sebum content at 8 weeks |
| The change of transepidermal water loss | Tewameter® TM300 was utilized to measure transepidermal water loss (TEWL). Units: TEWL-values lower than 70 g/hm² | Change from Baseline TEWL at 8 weeks |
| The change of L* (lightness) values | Spectrophotometer SCM-108 was utilized to measure skin L* value. Units: arbitrary units | Change from Baseline L* value at 8 weeks |
| The change of a* (redness) values | Spectrophotometer SCM-108 was utilized to measure skin a* value. Units: arbitrary units | Change from Baseline a* value at 8 weeks |
| The change of visible spots | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin hydration | Corneometer® CM825 was utilized to measure skin hydration. Units: arbitrary | Change from Baseline skin hydration at 8 weeks |
| The change of UV spots | VISIA Complexion Analysis System was utilized to measure UV spots. Units: arbitrary units |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hsiu-Mei Chiang, Prof. | China Medical University, China | Principal Investigator |
| Po-Yuan Wu, Dr. | China Medical University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China Medical University | Taichung | Taiwan |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| Wasabi Leaf Extract Drink |
| Dietary Supplement |
consume 1 bottle per day |
|
|
| Change from Baseline visible spots at 8 weeks |
| The change of skin red area | VISIA Complexion Analysis System was utilized to measure skin red area. Units: arbitrary units | Change from Baseline skin red area at 8 weeks |
| The change of total antioxidant capacity of blood | Venous blood was sampled to measure total antioxidant capacity | Change from Baseline total antioxidant capacity at 8 weeks |
| The change of Interleukin-6 of blood | Venous blood was sampled to measure IL-6 | Change from Baseline IL-6 at 8 weeks |
| The change of Interleukin-8 of blood | Venous blood was sampled to measure IL-8 | Change from Baseline IL-8 at 8 weeks |
| The change of Insulin-Like Growth Factor-1 of blood | Venous blood was sampled to measure IGF-1 | Change from Baseline IGF-1 at 8 weeks |
| Change from Baseline UV spots at 8 weeks |
| The change of brown spots | VISIA Complexion Analysis System was utilized to measure brown spots. Units: arbitrary units | Change from Baseline brown spots at 8 weeks |
| The change of Advanced glycation end products of blood | Venous blood was sampled to measure AGEs | Change from Baseline AGEs at 8 weeks |
| The change of liver function biomarkers (AST, ALT) of blood | Venous blood was sampled to measure liver function biomarkers | Change from Baseline liver function biomarkers at 8 weeks |
| The change of renal function biomarkers (creatinine, BUN) of blood | Venous blood was sampled to measure renal function biomarkers | Change from Baseline renal function biomarkers at 8 weeks |
| The change of fasting blood glugose level | Venous blood was sampled to measure fasting blood glugose level | Change from Baseline fasting blood glugose level at 8 weeks |
| The change of blood lipid profile | Venous blood was sampled to measure blood lipid profile (total cholesterol, HDL-C, LDL-C, triglyceride) | Change from Baseline blood lipid profile at 8 weeks |