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One of the main repercussions of POI is infertility. When the diagnosis of POI is announced, the question of fertility is addressed and the patient is often directed towards egg donation or adoption when she has a parental project. However, there are cases of spontaneous pregnancies after diagnosis.
This study was conducted to determine the proportion of patients with POI who were able to realize a parental project after diagnosis in the long term and by what means.
The investigators propose to study patients with POI who were hospitalized in the endocrinology and reproductive medicine department of the Pitié-Salpêtrière Hospital for the etiological assessment of ovarian failure and its consequences between December 31, 1982 and January 12, 2021. The investigators will only include patients who were admitted to the day hospital because we have a complete etiological workup and a complete history for them, which allows investigators to describe the population properly. The patients must be over 18 years old at the time of the survey in order to be able to evaluate the presence of a parental project only in adult patients.
Patients for whom there is no valid contact information in the computer file (postal address or valid email address or cell phone number) or whose last consultation was more than 2 years ago will be excluded. Patients with Turner syndrome will be excluded because they may have comorbidities, particularly cardiac, that contraindicate pregnancy. Patients with POI secondary to oncological treatments (gonadotoxic chemotherapy or pelvic radiotherapy) will also be excluded because of the uncertain prognosis and the contraindications to pregnancy in case of hormone-dependent tumors.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Survey | Other | Survey on the parental project and its realisation |
| Measure | Description | Time Frame |
|---|---|---|
| Realisation of parental project | Determine proportion of patient who realised a parental project after the diagnosis of POI | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Measure | Description | Time Frame |
|---|---|---|
| Determine how and to what extent they have carried out their parental project | Evaluation if, after the diagnosis of POI, the parental project was realized through: spontaneous pregnancy or egg donation, simple stimulation or in vitro fertilization, embryo reception, or the adoption of a child after the diagnosis of POI | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with POI who were hospitalized in a day hospital (HDJ) in the endocrinology and reproductive medicine department of the Pitié-Salpêtrière hospital for the etiological assessment of ovarian insufficiency and its repercussions between 31/12/1982 and 12/01/2021
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| Name | Affiliation | Role |
|---|---|---|
| Philippe Touraine, Pr | APHP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'endocrinologie et médecine de la reproduction | Paris | 75013 | France |
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| ID | Term |
|---|---|
| D016649 | Primary Ovarian Insufficiency |
| D007246 | Infertility |
| ID | Term |
|---|---|
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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| determine how many children on average these patients had after the diagnosis of POI. | Evaluation of the number of children born after the diagnosis of POI | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| determine the delay between the diagnosis of POI and the birth of the first child after the diagnosis according to the method | Evaluation of the time between the diagnosis of POI and the birth of the first child after diagnosis according to the method (egg donation, spontaneous pregnancy, adoption, etc.) | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o age at diagnosis | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o AMH level | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o FSH level | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o presence of follicles on ultrasound | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o cause of POI | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o number of pregnancies prior to diagnosis | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o number of children before diagnosis | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o normal puberty | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| Survey. Describe the characteristics of patients who were able to have a child after diagnosis | Evaluation of the characteristics of patients who were able to have a child after diagnosis: o age at menarche | data from patients with a diagnosis between 31/12/1982 and 12/01/2021 and whose opposition to the study is not expressed |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |