Safety Study of Tivanisiran to Treat Dry Eye

Safety Study of Tivanisiran to Treat Dry Eye

This study will examine the safety of tivanisiran sodium eye drops versus vehicle when dosed once daily for 1 year in subjects with signs and symptoms of dry eye disease (DED).

Inclusion Criteria:

• Be at least 18 years of age
• Have given their written consent to participate in the study
• Use of artificial tears (AT), autologous serum or specific dry eye medications during the last 6 months prior to the selection

Exclusion Criteria:

• Pregnant or breast feeding females with a postitive pregnancy test
• Women of childbearing potential not willing to use a medically acceptable contraceptive method
• Currently participating or has participated in another clinical trial within the 2 months prior to inclusion
• Current, previous chronic or recurrent medical condition that, according to the investigator, might impact on the study
• Any concomitant treatment or prior ocular procedure or surgery in either eye or alteration of the dose of systemic medications that could interfere in the trial