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The investigators will examine how a combination of pharmacological mineralocorticoid receptor (MR) stimulation and psychosocial stress will influence prosocial behavior in patients with Borderline Personality Disorder (BPD) compared to healthy controls (HC).
The investigators will examine whether MR stimulation enhances prosocial behavior in BPD patients under additional psychosocial stress. Participants will be randomly assigned to receive either fludrocortisone as an MR stimulant or placebo. Afterwards, participants will either undergo the stress or placebo condition of the Trier Social Stress Test ((P-)TSST). Subsequently, cognitive and emotional empathy, as well as sharing and punishment behavior will be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fludrocortisone & TSST - BPD patients | Experimental | intake of 0.4mg fludrocortisone (orally) before stress |
|
| Fludrocortisone & TSST - Healthy controls | Experimental | intake of 0.4mg fludrocortisone (orally) before stress |
|
| Placebo pills & TSST - BPD patients | Experimental | intake of placebo pill before stress |
|
| Placebo pills & TSST - Healthy controls | Experimental | intake of placebo pill before stress |
|
| Fludrocortisone & Placebo-TSST- BPD patients | Experimental | intake of 0.4mg fludrocortisone (orally) before "no stress" |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fludrocortisone | Drug | pill of fludrocortisone |
|
| Measure | Description | Time Frame |
|---|---|---|
| Empathy: Multifaceted Empathy Test | correct answers (mental state of the subject in the photos), rating of own emotional reaction | 15 minutes after (P-)TSST |
| Measure | Description | Time Frame |
|---|---|---|
| Sharing behavior | amount of monetary units (max 100) shared with co-player | 10 minutes after (P-)TSST |
| Punishment behavior | number of rejected offers from co-player |
| Measure | Description | Time Frame |
|---|---|---|
| salivary cortisol | treatment check | 3 hours |
| salivary alpha amylase | treatment check | 3 hours |
Inclusion Criteria "BPD group":
Inclusion Criteria "control group":
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite University | Berlin | Germany |
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| ID | Term |
|---|---|
| D001883 | Borderline Personality Disorder |
| ID | Term |
|---|---|
| D010554 | Personality Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D005438 | Fludrocortisone |
| D011581 | Psychological Tests |
| ID | Term |
|---|---|
| D006854 | Hydrocortisone |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
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| Fludrocortisone & Placebo-TSST - Healthy controls | Experimental | intake of 0.4mg fludrocortisone (orally) before "no stress" |
|
| Placebo pills & Placebo-TSST - BPD patients | Experimental | intake of placebo pill before "no stress" |
|
| Placebo pills & Placebo-TSST - Healthy controls | Experimental | intake of placebo pill before "no stress" |
|
| Placebo | Drug | placebo pill |
|
| Trier Social Stress Test (TSST) | Behavioral | psychosocial stress induction |
|
|
| Placebo Trier Social Stress Test (P-TSST) | Behavioral | control condition |
|
|
| 10 minutes after (P-)TSST |
| sex hormones | testosterone, estrogen, progesterone | 3 hours |
| D013256 |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D004191 | Behavioral Disciplines and Activities |