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In this before-after monocenter study, the authors teste the hypothesis that the implementation of a dedicated shock team could improve the outcome of patients with refractory cardiogenic shock assisted by mechanical circulatory support.
Short Term Mechanical Circulatory Support (STMCS) are the last resort therapeutics when refractory cardiogenic shock occurs. Growing technical possibilities like impella make the right choice at the right time challenging. At Bordeaux University Hospital, we have gathered the main protagonists which are the surgeon, the interventional cardiologist,and the intensivist as a shock team in January 2013. From that time, diagnosis of refractory cardiogenic shock triggers a multidisciplinary meeting driven by a common algorithm. The objective of this study is to perform a before-after comparison between decision of STMCS for refractory cardiogenic shock without shock team from january 2007 to january 2013 and after implementation of the shock team from April 2013 to April 2019.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Without Shock Team | Before January 2013, patients with refractory cardiogenic shock were implanted with short term mechanical circulatory device without involvment of a dedicated shock team |
| |
| With Shock Team | After April 2013, patients with refractory cardiogenic shock were implanted with short term mechanical circulatory device following a collegial meeting of a shock team (cardiac surgeon, cardiologist, intensivist) using a common algorythm. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| standard of care | Other | retrospective study : standard of care |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vital status | Proportion of patients alive | One year after short term mechanical circulatory support initiation |
| Measure | Description | Time Frame |
|---|---|---|
| Vital status | proportion of patients alive | 30 days after short term mechanical circulatory support initiation |
| Vital status | proportion of patients alive |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients with refractory cardiogenic shock treated with short term mechanical circulatory support between January 2007 to April 2019. A two months wash out period following shock team initiation (February and March 2013) has been set.
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| Name | Affiliation | Role |
|---|---|---|
| Alexandre Ouattara, MD, PhD | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bordeaux University Hospital | Pessac | 33604 | France |
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| ID | Term |
|---|---|
| D012770 | Shock, Cardiogenic |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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| 3 months after short term mechanical circulatory support initiation |
| Vital status | proportion of patients alive | 6 months after short term mechanical circulatory support initiation |
| Lenght of stay | Intensive Care Unit length of stay | up to Intensive Care Unit discharge, an average of 15 days |
| Lenght of stay | Hospital length of stay | up to one year |
| Long term mechanical circulatory support | proportion of patients bridged to long term mechanical circulatory support | up to intensive care unit discharge, an average of 15 days |
| Heart transplantation | proportion of patients bridged to heart transplantation | up to intensive care unit discharge, an average of 15 days |
| Weaning from short term mechanical circulatory support | proportion of patients sucessfully weaned from short term mechanical circulatory support | up to seven days from weaning attempt |
| New renal replacement therapy | proportion of patients needing renal replacement therapy | up to intensive care unit discharge, an average of 15 days |
| Limb ischaemia | proportion of patients with limb ischaemia | through short term mechanical circulatory support weaning, an average of 6 days |
| Stroke | proportion of patients with stroke | through short term mechanical circulatory support weaning, an average of 6 days |
| Short term mechanical circulatory support duration | Short term mechanical circulatory support duration | through short term mechanical circulatory support weaning, an average of 6 days |
| Severe haemorrage | proportion of patients with severe haemorrage (massive haemorrhage according to SFAR or use of Novoseven or rescue surgery for bleeding) | through short term mechanical circulatory support weaning, an average of 6 days |
| Extra Corporeal Membrane Oxygenation circuit clotting | proportion of patients in which Extra Corporeal Membrane Oxygenation circuit clotting occured | through short term mechanical circulatory support weaning, an average of 6 days |
| Sepsis | proportion of patients in which sepsis occured | up to intensive care unit discharge, an average of 15 days |
| Vital status | proportion of patients alive when bridged to long term mechanical circulatory device or when transplanted | One year after short term mechanical circulatory support initiation |
| Vital status | proportion of patients alive when bridged to long term mechanical circulatory device or when transplanted | 30 days after short term mechanical circulatory support initiation |
| Vital status | proportion of patients alive when bridged to long term mechanical circulatory device or when transplanted | 3 months after short term mechanical circulatory support initiation |
| Vital status | proportion of patients alive when bridged to long term mechanical circulatory device or when transplanted | 6 months after short term mechanical circulatory support initiation |
| D014652 |
| Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D012769 | Shock |