Integrating Enhanced HIV Pre-exposure Prophylaxis Into a Sexually Transmitted Infection Clinic in Lilongwe
Integrating Enhanced HIV Pre-exposure Prophylaxis Into a Sexually Transmitted Infection Clinic in Lilongwe
This is a prospective cohort study evaluating acceptability, feasibility, and effectiveness of integrating HIV pre-exposure prophylaxis (PrEP) into a sexually transmitted infection (STI) clinic alongside assisted partner notification and etiologic STI testing in Lilongwe, Malawi.
Patient Participant
Inclusion Criteria:
≥15 years of age.
Eligible for PrEP according to Malawi PrEP guidelines (see below)
Presenting for care at STI clinic (primary presentation or referral from partner based on STI or HIV exposure)
Able to consent for study participation and willing to provide locator information for follow-up tracing
*Malawi PrEP eligibility criteria:
Age ≥15 years
HIV seronegative iii. At substantial risk for HIV, with prioritization of persons who:
Buy or sell sex; Key population (female sex worker, men who have sex with other men, transgendered persons; Vulnerable population included adolescent girls and young women aged 15-24; STI clients; Serodiscordant couples including HIV-negative women who are pregnant or breast feeding or HIV-negative men or women for whom their HIV-infected partner is: not on ART, on ART <6 months, has an unsuppressed or high viral load, or is non-adherent to ART, iv. Have ruled out acute HIV infection, or defer PrEP initiation for anyone with signs or symptoms consistent with acute HIV infection, v. Willingness to attend scheduled PrEP visits, vi. No contraindication to use of TDF and 3TC, vii. Bodyweight ≥30 kg, viii. Estimated glomerular filtration rate (eGFR) ≥60mL/min, ix. No known renal diseases, x. No diabetes mellitus.
Exclusion Criteria:
Provider Participant:
Inclusion Criteria:
Exclusion Criteria:
- Unable or unwilling to provide informed consent