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The purpose of this study is to investigate the effects of a training program in patients that have suffered a COVID infection
Once patients have been selected and meet inclusion criteria, they will sign informed consent. They will make a first visit to obtain the basal parameters. Once done, they will start the individualized training program for 12 weeks 3 times a week.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training program | Active Comparator | Global intervallic exercise using cyclometer and analytical strength exercises |
|
| Training program + Inspiratory muscle traioning (IMT) | Experimental | Global intervallic exercise using cyclometer and analytical strength exercises + inspiratory muscles training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interval training + analytical strength | Other | Patients will receive a training program |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in walking distance in the 6 minutes walk test | 6MWT is a submaximal test performed in 30 meters corridor. | Baseline and 12 weeks after |
| Measure | Description | Time Frame |
|---|---|---|
| changes in the maximum watts generated | Cardiopulmonary exercise test will be performed as maximal test | Baseline and 12 weeks after |
| changes in (oxygen consumption) VO2 max | Cardiopulmonary exercise test will be performed as maximal test |
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Inclusion Criteria:
Men and women ≥18 years
Patients discharged from the Pulmonology Service with a diagnosis of COVID-19 by positive PCR and with severe pneumonia.
At least three months after the presence of at least one of the following criteria:
MRC dyspnea greater than or equal to 2.
Decrease in the meters walked with respect to the reference values in the 6-minute walking test.
C) Decreased respiratory muscle strength measured at Maximum Inspiratory Pressure (PIM) and / or Maximum Expiratory Pressure (PEM) with respect to reference values.
Sign informed consent from the study
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gerard Muñoz, PhD | Girona Biomedical Research Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Josep Trueta University Hospital | Girona | 17007 | Spain |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Interval training + analytical strength and IMT | Other | Patients will receive a training program + IMT |
|
| Baseline and 12 weeks after |
| changes in peak VO2 | Cardiopulmonary exercise test will be performed as maximal test | Baseline and 12 weeks after |
| changes in the diaphragmatic path | Diaphragm echocardiography will be performed | Baseline and 12 weeks after |
| changes in diaphragm thickness | Diaphragm echocardiography will be performed | Baseline and 12 weeks after |
| changes in diaphragmatic shortening | Diaphragm echocardiography will be performed | Baseline and 12 weeks after |
| changes in dyspnea | Measured with mMRC scale (scores from 0-4) | Baseline and 12 weeks after |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |