The study recruits breast cancer survivors who are already on chemotherapy or are going to start chemotherapy. Subjects will be asked for their preference to attend physiotherapy and educational class (for intervention group) or decline for it (for control group).

For intervention group, subject will attend 24 sessions of physiotherapy (exercise class) and 10 sessions of educational class over 12 weeks. The supervised 1-hour group exercise class will be conducted twice a week. Educational class will be once a week, with topics covering physical activity, management of fatigue, lymphoedema, neuropathy, brain fog, return to work, stress, nutrition, sexuality, psychosocial and caregiver issues.

Subjects in control group will be asked to exercise on their own in the 12 weeks.

12 weeks later, all subjects will attend a 2-hour survivorship transitional class, with topics covering cancer surveillance and follow up, addressing fear of recurrence: symptom and support, neuropathy/ fatigue/physical impairment/ brain fog, physical activity and diet, screening for colorectal and cervical cancers, return to work and community resources. During the class, a screening questionnaire will be administered to identify further physical, rehabilitation and psychosocial needs and to triage these patients to relevant hospital and community services.

Outcome assessment will be done at pre-intervention, after intervention, 6 months and 1 year after the intervention.

This study will be a mixed study of both quantitative and qualitative research to investigate the effect of the holistic program of combining patient education and intra chemotherapy on cancer survivorship.

80 breast cancer survivors will be recruited from National University Cancer Institute, Singapore (NCIS). Breast cancer survivors who are already on chemotherapy or are going to start chemotherapy will be recruited.

Subjects will be asked their preference to attend physiotherapy and educational class (for intervention group) or decline for it (for control group). The study is not randomized as challenges in subject recruitment are expected otherwise. Patients in intervention group will attend a program combining 24 sessions of physiotherapy and 10 sessions of educational class over 12 weeks. Subjects in control group will be asked to exercise on their own.

The first visit for both groups will be an individual evaluation session by physiotherapist (PT), occupational therapist (OT), and study coordinator. Baseline assessments of outcome measures will be performed during the visit. PT and OT will also prescribe an individualized home exercise program for subjects in both groups.

Subsequent visits for intervention group will be 24 sessions of physiotherapy (exercise class) and 10 sessions of educational class over 12 weeks. The supervised 1-hour group exercise class will be conducted twice a week, with a maximum of 8 patients in each class. Subjects will be given a home log for exercise recording. If subjects are unable to attend exercise class for any reason (eg., low counts or feeling unwell, etc.), they will be advised to continue exercises at home. On the day of one of the exercise classes each week, there will be an additional 1-hour group education/ discussion session which may be conducted by PT, OT, APN, dietician or medical social worker. Topics covered will include physical activity, management of fatigue, lymphoedema, neuropathy, brain fog, return to work, stress, nutrition, sexuality, psychosocial and caregiver issues. There will be 10 sessions of educational class in total for each subject.

After completing all exercise classes and educational classes for subjects in intervention group, or after12 weeks' home exercise for subjects in control group, all subjects in both group will attend a 2-hour survivorship transitional class, which will be held in groups of up to 10 subjects. During the class, the trainer (usually APN) will educate and provide an overview of breast cancer survivorship issues, seek to empower with self-assessment skills and provide cancer survivors with information on available community resources. The class seeks to reintegrate cancer survivors back to the community and will also serve as a platform to screen for and identify those with further psychosocial and rehabilitation needs and triage them accordingly to the relevant hospital or community resources. The topics that will be covered in education will include cancer surveillance and follow up, addressing fear of recurrence: symptom and support, neuropathy/ fatigue/physical impairment/ brain fog, physical activity and diet, screening for colorectal and cervical cancers, return to work and community resources. During the class, a screening questionnaire will be administered to identify further physical, rehabilitation and psychosocial needs and to triage these patients to relevant hospital and community services.

The subsequent 2 visits for both groups will be outcome assessment. One is after the survivorship transitional class, and the other one is at 1 year after the survivorship transitional class. Outcome measures will be administered by PT, OT, and study coordinator.

Inclusion Criteria:

1. Females between 21 - 80 years old;
2. Breast cancer patients before or already on the treatment of chemotherapy, targeted therapy, and/or radiotherapy;
3. Be able to provide consent and complete questionnaires;
4. Be able to walk independently in the community without use of gait aids.
5. Breast cancer patients who are suitable for exercise.

Exclusion Criteria:

1. Pregnant;
2. Uncontrolled hypertension (Resting BP >160/90 mm Hg), or history of recurring or persistent hypotension in the past 2 months;
3. History of recent myocardial infarction or unstable angina (within the past 6 months);
4. Significant valvular disease i.e. severe aortic stenosis and moderate-severe mitral regurgitation;
5. Patient with end stage organ disease (e.g. ESRF, end stage COPD);
6. Tumor infiltration of axial or weight-bearing bones with risk of pathological fractures or compression of the spinal cord;
7. Patient with recent stroke within the past 6 months;
8. With other neuromusculoskeletal disorders such as osteoarthritis of such severity as to limit ability to participate in group exercise classes;
9. Already participating in regular physical activity (150min of moderate or 75min of vigorous physical activity/week);
10. Deemed inappropriate by primary oncologists.

Only females will be recruited