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The main goals of the study are to assess uptake and distribution of Lu AF90103 in the brain when given at tracer levels (microdose) in healthy young men.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| [11C]-Lu AF90103 | Experimental | Participants will receive [11C]-Lu AF90103 via an intravenous bolus injection on Day 1. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [11C]-Lu AF90103 | Drug | PET ligand administrated as a single intravenous bolus injection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area Under the Time-Activity Curves for Brain up to 90 Minutes (AUCbrain 0-90 min) | Day 1 (predose and up to 90 minutes postdose) | |
| Area Under the Blood Concentrations Over Time for [11C]-Lu AF90103 and Radioactive Metabolites up to 90 Minutes (AUCblood 0-90 min) | Day 1 (predose and up to 90 minutes postdose) | |
| Area Under the Plasma Concentrations Over Time for [11C]-Lu AF90103 and Radioactive Metabolites up to 90 Minutes (AUCplasma 0-90 min) | Day 1 (predose and up to 90 minutes postdose) | |
| Whole Brain-to-Plasma Ratio Expressed by AUCbrain 0-90 min/AUCplasma 0-90 min | Day 1 (predose and up to 90 minutes postdose) | |
| Total Distribution Volume in the Whole Brain (VT brain) | Day 1 (predose and up to 90 minutes postdose) | |
| Ratio Between the Free Concentrations [11C]-Lu AF90103 in Brain Tissue and Plasma (Kp,uu) | Day 1 (predose and up to 90 minutes postdose) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Email contact via H. Lundbeck A/S | H. Lundbeck A/S | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Trial Alliance | Huddinge | 141 86 | Sweden |
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