Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bilateral rapid magnetic stimulation of the phrenic nerves | Experimental | Each participant will be tested on three different days with optimal settings for bilateral rapid magnetic stimulation of the phrenic nerves established on visit 1 and then repeated on visits 2 and 3. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic phrenic nerve stimulation | Other | The intervention consists of bilateral rapid magnetic phrenic nerve stimulation on the neck using different stimulation intensities. On one visit, the effect of increasing chest wall stiffness and respiratory muscle work by adding incrementally small weights to the chest/abdomen will be investigated. |
| Measure | Description | Time Frame |
|---|---|---|
| Diaphragm contractility | Transdiaphragmatic pressure changes, i.e. changes in esophageal and gastric pressures, will be measured by a pressure transducer connected to balloon-catheters. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Changes in airflow | Flow will be recorded by a pneumotachometer and averaged over breaths. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Changes in chest and abdominal movements |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Christina M. Spengler, Prof. | ETH Zurich, Exercise Physiology Lab, Institute of Human Movement Sciences and Sport | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich | Zurich | Canton of Zurich | 8092 | Switzerland |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
Chest and abdominal movements will be assessed using respiratory belt strain transducers.
| Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Changes in costal diaphragm activity | Costal diaphragm activity will be continuously recorded via a wireless surface electromyography system. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Head, shoulder and arm accelerations | Head, shoulder and arm movements will be recorded using wireless acceleration sensors attached to the head and arms. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Body movement | Overall body movement incl. head, shoulder and arm movements will be recorded using a video camera. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Changes in skin conductance | Skin conductance (μS) will be continuously recorded with electrodes worn on two fingers. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Changes in heart rate | Heart rate will will be continuously recorded beat by beat (1/min) with electrodes on both wrists and one ankle. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Changes in blood pressure | Systolic and diastolic blood pressure (mmHg) will be continuously recorded using a non-invasive device. | Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |
| Perception of pain, paresthesia and discomfort | Participant subject perception of pain, paresthesia and discomfort will be evaluated with 0-to-10-point scale, with 0 = no pain/paresthesia/discomfort and 10 = maximal pain/paresthesia/discomfort. Higher values indicate more perception of the specified sensations. | Assessed 10 sec after each stimulation. One stimulation lasts for approx. 1 sec. |