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The aim of the study is to analyze the variability of plethysmography curve depending on the breath cycle (respiratory rate and tidal volume).
The plethysmography curve measured by finger sensors using pulse oximetry shows the changes in blood volume at the measured site. The presence of respiratory information within the pulse oximeter signal is a well-documented phenomenon. However, previous studies have mainly focused on extracting the respiratory rate from the plethysmography curve. The aim of this study is to analyze the variability of plethysmography curve as a function of both respiratory rate and tidal volume. Furthermore, the aim is to analyze the possibilities of apneic pause detection from the plethysmography curve.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Measurement of plethysmography curve | Experimental | Calm measurement of plethysmography curve using pulse oximetry with simultaneous monitoring of the breath cycle. In this experimental arm, participants will vary their breath cycle (different respiratory rates and different tidal volumes). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Respiratory rate | Other | The participant alternates respiratory rates of 30, 15 and 7.5 breaths/min. Breathe each frequency for 2 minutes with a one-minute break. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Variability of plethysmography curve depending on the respiratory rate | The effect of different respiratory rates (including apnea-zero respiratory rate) on the shape of the plethysmography curve will be evaluated. | 1 hour |
| Variability of plethysmography curve depending on the tidal volume | The effect of different tidal volumes (including apnea-zero tidal volume) on the shape of the plethysmography curve will be evaluated. | 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Veronika Rafl Huttova, MSc | Czech Technical University in Prague | Principal Investigator |
| Jakub Rafl, PhD | Czech Technical University in Prague | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Biomedical Engineering, Czech Technical University in Prague | Kladno | 27201 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23449854 | Background | Nilsson LM. Respiration signals from photoplethysmography. Anesth Analg. 2013 Oct;117(4):859-865. doi: 10.1213/ANE.0b013e31828098b2. Epub 2013 Feb 28. |
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| ID | Term |
|---|---|
| D001049 | Apnea |
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D056152 | Respiratory Rate |
| D013990 | Tidal Volume |
| C086112 | N(6)-2-(4-aminophenyl)ethyladenosine |
| ID | Term |
|---|---|
| D055986 | Vital Signs |
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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All participants go through all assigned interventions in one study arm.
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| Tidal volume | Other | The participant alternates tidal volumes of approx. 2, 1 and 0.5 litres. Breathe each tidal volume for 2 minutes with a one-minute break. |
|
| Apnea | Other | The participant simulates three apneic pauses lasting 1 minute with a two-minute break. |
|
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
| D012119 |
| Respiration |
| D012143 | Respiratory Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
| D007320 | Inspiratory Capacity |
| D014797 | Vital Capacity |
| D014109 | Total Lung Capacity |
| D008176 | Lung Volume Measurements |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |