Breast MRI in Evaluation of Pathologic Response in Patients With Breast Cancer With Neoadjuvent Chemotherapy

Added Value of Breast MRI in Evaluation of Pathologic Response in Patients With Locally Advanced Breast Cancer Who Undergo Neoadjuvent Chemotherapy

evaluation of pathological response in breast mass by use of breast MRI in patients receiving neoadjuvent chemotherapy via comparison with pathological results

evaluation of pathological response in locally advanced breast masses by use of breast MRI in patients receiving neoadjuvent chemotherapy via comparison with pathological results

Inclusion Criteria:

• all women referred to the radiology department for breast MRI examination either for screening, evaluation of suspicious lesions onsono-mammography \

  • Patients with locally advanced breast cancer
  • Patients with early stage breast cancer and chemo-responsive tumour markers (i.e. triple negative, Her2+), who will benefit from downsizing for breast conserving surgery (BCS)
  • Absolute or Relative contraindications to surgery (advanced age/multiple medical comorbidities) in the setting of estrogen receptor positive tumours (for consideration of neoadjuvant endocrine therapy)3
  • Patients must be elder than 18 years old.

• patients with accepted renal function

Exclusion Criteria:

• Patients with metastatic breast cancer.
• Patient with breast mass more than 5 cm .
• Patients with fungating breast mass .
• Patients with stage IV [tumor spread to chest wall and to skin ].
• pregnant women especially in 1th trimester.
• Patient with presence of any paramagnetic substance as pacemakers.
• severely ill patients .
• patients with claustrophobia.
• arrhythmic patients